Document Detail

Blood pH and the actions of nifedipine on cardiac excitation-contraction coupling.
MedLine Citation:
PMID:  1425966     Owner:  NLM     Status:  MEDLINE    
Hearts from male Sprague-Dawley rats were perfused, by the Lagendorff method, with calcium-free Krebs solution (containing either adrenaline or a high level of potassium) at pH 7.48 (control), 7.26 (acidosis) or 7.69 (alkalosis). When the hearts stopped contracting, a dose of nifedipine or its vehicle was given before measuring the force of contraction, coronary perfusion pressure and heart rate in response to graded doses of calcium. The calcium-antagonising efficacy of nifedipine was reduced during acidosis in both adrenaline- and potassium-stimulated hearts, but the reduction was greater in the adrenaline-stimulated hearts. Alkalosis led to a small increase in the efficacy of nifedipine on adrenaline- and potassium-stimulated contractions.
F I Achike; S Dai; C W Ogle
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  219     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
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MeSH Terms
Epinephrine / pharmacology
Hydrogen-Ion Concentration
Myocardial Contraction / drug effects*
Nifedipine / pharmacology*
Potassium / pharmacology
Rats, Sprague-Dawley
Reg. No./Substance:
21829-25-4/Nifedipine; 51-43-4/Epinephrine; 7440-09-7/Potassium

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