| Blood oxygen level-dependent signal variability is more than just noise. | |
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MedLine Citation:
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PMID: 20371811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional magnetic resonance imaging (fMRI) research often attributes blood oxygen level-dependent (BOLD) signal variance to measurement-related confounds. However, what is typically considered "noise" variance in data may be a vital feature of brain function. We examined fMRI signal variability during fixation baseline periods, and then compared SD- and mean-based spatial patterns and their relations with chronological age (20-85 years). We found that not only was the SD-based pattern robust, it differed greatly, both spatially and statistically, from the mean-based pattern. Notably, the unique age-predictive power of the SD-based pattern was more than five times that of the mean-based pattern. This reliable SD-based pattern of activity highlights an important "signal" within what is often considered measurement-related "noise." We suggest that examination of BOLD signal variability may reveal a host of novel brain-related effects not previously considered in neuroimaging research. |
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Authors:
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Douglas D Garrett; Natasa Kovacevic; Anthony R McIntosh; Cheryl L Grady |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 4914-21 Citation Subset: IM |
Affiliation:
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Rotman Research Institute, Baycrest, Toronto, Ontario M6A 2E1, Canada. d.garrett@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Brain / metabolism Electricity / adverse effects* Female Humans Magnetic Resonance Imaging / methods, standards* Male Middle Aged Oxygen / blood* Reproducibility of Results Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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MOP13026//Canadian Institutes of Health Research; MOP14036//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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