| Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys. | |
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MedLine Citation:
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PMID: 19577402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional magnetic resonance imaging (fMRI) is a powerful tool for examining kidney function, including organ blood flow and oxygen bioavailability. We have used contrast enhanced perfusion and blood oxygen level-dependent (BOLD) MRI to assess kidney transplants with normal function, acute tubular necrosis (ATN) and acute rejection. BOLD and MR-perfusion imaging were performed on 17 subjects with recently transplanted kidneys. There was a significant difference between medullary R2 values in the group with acute rejection (R2=16.2/s) compared to allografts with ATN (R2=19.8/s; P=.047) and normal-functioning allografts (R2=24.3/s;P=.0003). There was a significant difference between medullary perfusion measurements in the group with acute rejection (124.4+/-41.1 ml/100 g per minute) compared to those in patients with ATN (246.9+/-123.5 ml/100 g per minute; P=.02) and normal-functioning allografts (220.8+/-95.8 ml/100 g per minute; P=.02). This study highlights the utility of combining perfusion and BOLD MRI to assess renal function. We have demonstrated a decrease in medullary R2 (decrease deoxyhemoglobin) on BOLD MRI and a decrease in medullary blood flow by MR perfusion imaging in those allografts with acute rejection, which indicates an increase in medullary oxygen bioavailability in allografts with rejection, despite a decrease in blood flow. |
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Authors:
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Elizabeth A Sadowski; Arjang Djamali; Andrew L Wentland; Rebecca Muehrer; Bryan N Becker; Thomas M Grist; Sean B Fain |
Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-07-03 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 56-64 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Wisconsin, Madison, WI 53792, USA. esadowski@uwhealth.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity* Female Humans Kidney / blood supply, physiopathology* Kidney Transplantation* Magnetic Resonance Angiography / methods* Middle Aged Oxygen / blood* Reproducibility of Results Sensitivity and Specificity Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R33 DK070243-03/DK/NIDDK NIH HHS; R33 DK070243-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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