| Blood-oxygen affinity and sickling in sickle cell disease: effect of prior deoxygenation. | |
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MedLine Citation:
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PMID: 6793678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of prior deoxygenation on whole blood-oxygen affinity was determined in samples from persons with sickle cell anemia (SS blood) and compared to blood from normal and anemic subjects (AA blood). The oxygen affinity of SS blood (measured as P50) is significantly decreased when this blood is exposed for 30 min to nitrogen before the determination of the oxygen equilibrium curve. The decrease is directly related to the number of sickle cells that are present in the samples. The present work emphasizes the importance of experimental conditions on the results of the determination of SS blood-oxygen affinity and the difficulties inherent in the evaluation of in vivo oxygen transport in sickle cell disease. |
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Authors:
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M Sinet; J J Pocidalo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 98 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1981-12-15 Completed Date: 1981-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 492-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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blood Anemia, Sickle Cell / blood* Carbon Dioxide / blood Hemoglobin, Sickle / analysis Humans Oxygen / blood* Sickle Cell Trait / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin, Sickle; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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