Document Detail


Blood monoamine oxidases and CT scans in subgroups of chronic schizophrenics.
MedLine Citation:
PMID:  6333507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An assay method for monoamine oxidase (MAO) employing whole blood samples is described. With this method, whole blood samples collected from three subgroups of chronic schizophrenic patients were assayed directly for MAOb activity without the need for prior isolation of platelets. Our results support previous findings from assays with platelets that chronic paranoid schizophrenics have decreased blood MAOb activity compared to chronic non-paranoid schizophrenics or normal controls. The level of MAOb activity in the blood of the non-paranoid schizophrenics was also linearly correlated with ventricular size (i.e. ventricular brain ratio, VBR) as determined by CT scan analysis. This correlation was not true for the paranoid group. The MAOb data in conjunction with the VBR data were sufficient to divide without overlap our schizophrenic patient population into two clinically defined subgroups.
Authors:
K H Tachiki; N Kurtz; A S Kling; F J Hullett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  18     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-04     Completed Date:  1984-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Atrophy
Brain / radiography*
Cerebral Ventriculography
Chronic Disease
Clinical Enzyme Tests*
Humans
Middle Aged
Monoamine Oxidase / blood*
Schizophrenia / diagnosis*
Schizophrenia, Paranoid / diagnosis
Tomography, X-Ray Computed*
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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