Document Detail

Blood and milk immune and inflammatory profiles in periparturient dairy cows showing a different liver activity index.
MedLine Citation:
PMID:  20576169     Owner:  NLM     Status:  MEDLINE    
This paper reports the results of a study that aimed to assess whether liver functionality defined by liver activity index (LAI) is associated with inflammatory and immune parameters in blood and milk. LAI is an index including the average blood levels of albumin, lipoproteins and retinol-binding protein measured three times in the first month of lactation (at 5, 15 and 30 days in milk). The aim was to assess the relationship of this index with blood and udder immune and inflammatory status as a means of identifying as early as possible cows at risk of disease. The research was carried out using 10 multiparous Italian-Friesian dairy cows of average genetic merit. Cows were retrospectively ranked in three groups according the LAI level. Blood samplings were performed at different intervals before and after calving; quarter milk samples were taken only after calving with the same schedule as blood samples. Leucocytes, oxidative burst, blood lysozyme and N-acetyl-beta-d-glucosaminidase (NAGase) curves showed large overlapping among the three LAI group curves during the follow-up period. Four blood (complement, sialic acid, haptoglobin and reactive oxygen metabolites) and three milk (somatic cell count, lysozyme and NAGase) parameters showed larger and more consistent differences among LAI groups. Complement showed higher values and sialic acid showed lower values in high LAI group when compared with the other two LAI groups. Two other markers of inflammatory status (haptoglobin and reactive oxygen metabolites) showed the lowest values in high LAI cows. A consistent and significant reduction of milk NAGase and milk lysozyme in high LAI group was observed. The results suggest that cows with the highest liver functionality index have also the highest levels of some immune markers and the lowest levels for inflammatory markers at blood (already before calving) and mammary levels. Finally, cows with low LAI index, being more susceptible to metabolic and infectious diseases, should be carefully monitored to identify as early as possible the development of a disease.
Erminio Trevisi; Alfonso Zecconi; Giuseppe Bertoni; Renata Piccinini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of dairy research     Volume:  77     ISSN:  1469-7629     ISO Abbreviation:  J. Dairy Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985125R     Medline TA:  J Dairy Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-7     Citation Subset:  IM    
Istituto di Zootecnica, Facoltà di Agraria, Università Cattolica del Sacro Cuore, via Emilia Parmense, 84, 29100 Piacenza, Italy.
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MeSH Terms
Acetylglucosaminidase / analysis,  blood
Cattle / blood,  immunology*
Cattle Diseases / blood,  diagnosis,  immunology
Complement System Proteins / analysis
Haptoglobins / analysis
Inflammation / blood,  diagnosis,  veterinary*
Lactation / blood,  immunology,  metabolism
Leukocyte Count / veterinary
Lipoproteins / blood
Liver / metabolism*
Milk / chemistry,  immunology*
Muramidase / analysis,  blood
N-Acetylneuraminic Acid / blood
Reactive Oxygen Species / blood
Retinol-Binding Proteins / analysis
Serum Albumin / analysis
Reg. No./Substance:
0/Haptoglobins; 0/Lipoproteins; 0/Reactive Oxygen Species; 0/Retinol-Binding Proteins; 0/Serum Albumin; 131-48-6/N-Acetylneuraminic Acid; 9007-36-7/Complement System Proteins; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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