Document Detail

Blood and milk concentrations of ampicillin in mothers treated with pivampicillin and in their infants.
MedLine Citation:
PMID:  3452637     Owner:  NLM     Status:  MEDLINE    
The levels of ampicillin were determined in milk and plasma of 14 lactating mothers in treatment with pivampicillin for puerperal infections and in plasma of their suckling infants. Ampicillin could not be detected in plasma of the infants, i.e. all levels were less than 0.03 micrograms/ml. Maximum levels occurred in plasma 60-120 minutes and in milk 180-240 minutes after medication. Milk-plasma ratios varied between 0.01 and 0.58. The highest level of ampicillin in milk was 1.02 micrograms/ml in a woman receiving pivampicillin tablets 700 mg t.d.s. At this level an infant can at the most ingest 0.5 mg/day. This dose is too small to cause any symptoms in the suckling infants, but allergic sensibilization through the milk is possible.
P E Branebjerg; L Heisterberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  15     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1987  
Date Detail:
Created Date:  1988-08-08     Completed Date:  1988-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  555-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology G, Gentofte Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Ampicillin / analogs & derivatives*,  analysis*,  blood
Infant, Newborn
Milk, Human / analysis*
Pivampicillin / therapeutic use*
Protein Binding
Puerperal Infection / drug therapy
Reg. No./Substance:
33817-20-8/Pivampicillin; 69-53-4/Ampicillin

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