| Blood and milk concentrations of ampicillin in mothers treated with pivampicillin and in their infants. | |
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MedLine Citation:
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PMID: 3452637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of ampicillin were determined in milk and plasma of 14 lactating mothers in treatment with pivampicillin for puerperal infections and in plasma of their suckling infants. Ampicillin could not be detected in plasma of the infants, i.e. all levels were less than 0.03 micrograms/ml. Maximum levels occurred in plasma 60-120 minutes and in milk 180-240 minutes after medication. Milk-plasma ratios varied between 0.01 and 0.58. The highest level of ampicillin in milk was 1.02 micrograms/ml in a woman receiving pivampicillin tablets 700 mg t.d.s. At this level an infant can at the most ingest 0.5 mg/day. This dose is too small to cause any symptoms in the suckling infants, but allergic sensibilization through the milk is possible. |
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Authors:
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P E Branebjerg; L Heisterberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 15 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 1987 |
Date Detail:
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Created Date: 1988-08-08 Completed Date: 1988-08-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 555-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology G, Gentofte Hospital, University of Copenhagen, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ampicillin
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analogs & derivatives*,
analysis*,
blood Female Humans Infant Infant, Newborn Milk, Human / analysis* Pivampicillin / therapeutic use* Pregnancy Protein Binding Puerperal Infection / drug therapy |
| Chemical | |
Reg. No./Substance:
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33817-20-8/Pivampicillin; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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