| Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report. | |
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MedLine Citation:
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PMID: 15375077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought. |
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Authors:
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C A Williams; M R Wallace; K C Drury; S Kipersztok; R K Edwards; R S Williams; M J Haller; D A Schatz; J H Silverstein; B A Gray; R T Zori |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2004-09-16 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 19 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-05-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2816-21 Citation Subset: IM |
Affiliation:
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The R.C.Philips Unit, Division of Genetics, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA. Willicx@peds.ufl.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chimera* Chorion Diseases in Twins / genetics Endocrine System / metabolism Female Fertilization in Vitro* Fibroblasts / physiology Genitalia / abnormalities Humans In Situ Hybridization, Fluorescence Infant Infant, Newborn Lymphocytes / physiology* Male Microsatellite Repeats Mosaicism Ovary / abnormalities Pregnancy Skin / cytology Twins, Dizygotic / genetics* Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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