| Blood levels of bupivacaine after single dose, supplementary dose and during continuous infusion in axillary plexus block. | |
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MedLine Citation:
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PMID: 6637355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The material consisted of 25 patients undergoing orthopaedic or plastic surgery of the upper extremity, including seven cases of replantation surgery. The total doses of bupivacaine, 150-267 mg as a single dose, 280-440 mg as a supplementary dose and 247-629 mg as a continuous infusion, resulted in maximum venous concentrations of 0.68-3.33 micrograms/ml, 1.21-2.44 micrograms/ml and 0.51-1.89 micrograms/ml, respectively. These usually occurred 30-60 min after the injection of bupivacaine and always following the second injection when a supplementary dose was needed. The highest individual value noted occurred 15 min after single injection, possibly as a result of an exceptionally rapid absorption. Despite the high doses and the rather high venous peak concentration of bupivacaine in some of the patients, no toxic side-effects were observed during the block or during the recovery period. |
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Authors:
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M Tuominen; P H Rosenberg; E Kalso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 27 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 303-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bupivacaine / administration & dosage, blood* Female Hand / surgery Humans Infusions, Parenteral Injections Male Middle Aged Nerve Block* Preanesthetic Medication Time Factors |
| Chemical | |
Reg. No./Substance:
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2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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