| Blood lead level and kidney function in US adolescents: The Third National Health and Nutrition Examination Survey. | |
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MedLine Citation:
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PMID: 20065202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic, high-level lead exposure is a known risk factor for kidney disease. The effect of current low-level environmental lead exposure is less well known, particularly among children, a population generally free from kidney disease risk factors such as hypertension and diabetes mellitus. Therefore, in this study, we investigated the association between lead exposure and kidney function in a representative sample of US adolescents. METHODS: Participants included 769 adolescents aged 12 to 20 years for whom whole blood lead and serum cystatin C were measured in the Third National Health and Nutrition Examination Survey, conducted from 1988-1994. The association between blood lead level and level of kidney function (glomerular filtration rate [GFR]), determined by cystatin C-based and creatinine-based estimating equations, was examined. RESULTS: Median whole blood lead level was 1.5 microg/dL (to convert to micromoles per liter, multiply by 0.0483), and median cystatin C-estimated GFR was 112.9 mL/min/1.73 m(2). Participants with lead levels in the highest quartile (> or =3.0 microg/dL) had 6.6 mL/min/1.73 m(2)-lower estimated GFR (95% confidence interval, -0.7 to -12.6 mL/min/1.73 m(2)) compared with those in the first quartile (<1 microg/dL). A doubling of blood lead level was associated with a 2.9 mL/min/1.73 m(2)-lower estimated GFR (95% confidence interval, -0.7 to -5.0 mL/min/1.73 m(2)). Lead levels were also associated with lower creatinine-based estimated GFR levels, but the association was weaker than with cystatin C-based GFR and not statistically significant. CONCLUSIONS: Higher blood lead levels in a range below the current Centers for Disease Control and Prevention-designated level of concern (10 microg/dL) were associated with lower estimated GFRs in a representative sample of US adolescents. This finding contributes to the increasing epidemiologic evidence indicating an adverse effect of low-level environmental lead exposure. |
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Authors:
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Jeffrey J Fadrowski; Ana Navas-Acien; Maria Tellez-Plaza; Eliseo Guallar; Virginia M Weaver; Susan L Furth |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of internal medicine Volume: 170 ISSN: 1538-3679 ISO Abbreviation: Arch. Intern. Med. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-12 Completed Date: 2010-02-26 Revised Date: 2011-06-09 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 75-82 Citation Subset: AIM; IM |
Affiliation:
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Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. jfadrow1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Creatinine / blood Cystatin C / blood Female Glomerular Filtration Rate* Humans Kidney Function Tests Lead / blood* Lead Poisoning / blood, epidemiology Linear Models Male Nutrition Surveys* Risk Factors United States / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K23 ES016514-05/ES/NIEHS NIH HHS; K23ES016514/ES/NIEHS NIH HHS; K24DK078737/DK/NIDDK NIH HHS; U01DK066174/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cystatin C; 60-27-5/Creatinine; 7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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