Document Detail

Blood lead at currently acceptable levels may cause preterm labour.
MedLine Citation:
PMID:  20798002     Owner:  NLM     Status:  In-Data-Review    
Objectives Although occupational and environmental exposures to lead have been dramatically reduced in recent decades, adverse pregnancy outcomes have been observed at 'acceptable' levels of blood lead concentrations (≤10 μg/dl). Methodology Blood samples were collected from 348 singleton pregnant women, aged 16-35 years, during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Subjects were followed up and divided into two groups (preterm and full-term deliveries) according to duration of gestation. Results The average (range) and geometric means of blood lead levels were 3.8 (1.0-20.5) and 3.5 μg/dl, respectively. Blood lead level was significantly (p<0.05) higher in mothers who delivered preterm babies than in those who delivered full-term babies (mean±SD: 4.46±1.86 and 3.43±1.22 μg/dl, respectively). Logistic regression analysis demonstrated that a 1 unit increase in blood lead levels led to an increased risk of preterm birth (OR 1.41, 95% CI 1.08 to 1.84). Conclusion Adverse pregnancy outcomes may occur at blood lead concentrations below the current acceptable level.
Mohsen Vigeh; Kazuhito Yokoyama; Zahrabigom Seyedaghamiri; Atsuko Shinohara; Takehisa Matsukawa; Momoko Chiba; Masoud Yunesian
Publication Detail:
Type:  Journal Article     Date:  2010-08-26
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  68     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
National Institute of Occupational Safety and Health, 6-21-6 Nagao, Tama-ku, Kawasaki 214-8585, Japan;
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