| Blood lead at currently acceptable levels may cause preterm labour. | |
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MedLine Citation:
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PMID: 20798002 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives Although occupational and environmental exposures to lead have been dramatically reduced in recent decades, adverse pregnancy outcomes have been observed at 'acceptable' levels of blood lead concentrations (≤10 μg/dl). Methodology Blood samples were collected from 348 singleton pregnant women, aged 16-35 years, during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Subjects were followed up and divided into two groups (preterm and full-term deliveries) according to duration of gestation. Results The average (range) and geometric means of blood lead levels were 3.8 (1.0-20.5) and 3.5 μg/dl, respectively. Blood lead level was significantly (p<0.05) higher in mothers who delivered preterm babies than in those who delivered full-term babies (mean±SD: 4.46±1.86 and 3.43±1.22 μg/dl, respectively). Logistic regression analysis demonstrated that a 1 unit increase in blood lead levels led to an increased risk of preterm birth (OR 1.41, 95% CI 1.08 to 1.84). Conclusion Adverse pregnancy outcomes may occur at blood lead concentrations below the current acceptable level. |
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Authors:
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Mohsen Vigeh; Kazuhito Yokoyama; Zahrabigom Seyedaghamiri; Atsuko Shinohara; Takehisa Matsukawa; Momoko Chiba; Masoud Yunesian |
Publication Detail:
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Type: Journal Article Date: 2010-08-26 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 68 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 231-4 Citation Subset: IM |
Affiliation:
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National Institute of Occupational Safety and Health, 6-21-6 Nagao, Tama-ku, Kawasaki 214-8585, Japan; vigeh@h.jniosh.go.jp. |
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