Document Detail


Blood lactate exchange and removal abilities after relative high-intensity exercise: effects of training in normoxia and hypoxia.
MedLine Citation:
PMID:  11417427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 4 weeks of endurance training in conditions of normoxia or hypoxia on muscle characteristics and blood lactate responses after a 5-min constant-load exercise (CLE) at 90% of the power corresponding to the maximal oxygen uptake were examined at sea-level in 13 sedentary subjects. Five subjects trained in normobaric hypoxia (HT group, fraction of oxygen in inspired gas = 13.2%), and eight subjects trained in normoxia at the same relative work rates (NT group). The blood lactate recovery curves from the CLE were fitted to a biexponential time function: La(t) = La(0) + A1(1 - e- gamma 1.t) + A2(1 - e- gamma 2.t), where the velocity constants gamma 1 and gamma 2 denote the lactate exchange and removal abilities, respectively, A1 and A2 are concentration parameters that describe the amplitudes of concentration variations in the space represented by the arterial blood, La(t) is the lactate concentration at time t, and La(0) is the lactate concentration at the beginning of recovery from CLE. Before training, the two groups displayed the same muscle characteristics, blood lactate kinetics after CLE, and gamma 1 and gamma 2 values. Training modified their muscle characteristics, blood lactate kinetics and the parameters of the fits in the same direction, and proportions among the HT and the NT subjects. Endurance training increased significantly the capillary density (by 31%), citrate synthase activity (by 48%) and H isozyme proportion of lactate dehydrogenase (by 24%), and gamma 1 (by 68%) and gamma 2 (by 47%) values. It was concluded that (1) endurance training improves the lactate exchange and removal abilities estimated during recovery from exercises performed at the same relative work rate, and (2) training in normobaric hypoxia results in similar effects on lactate exchange and removal abilities to training in normoxia performed at the same relative work rates. These results, which were obtained non-invasively in vivo in humans during recovery from CLE, are comparable to those obtained in vitro or by invasive methods during exercise and subsequent recovery.
Authors:
L Messonnier; H Freund; L Féasson; F Prieur; J Castells; C Denis; M T Linossier; A Geyssant; J R Lacour
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology     Volume:  84     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-21     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  403-12     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie de l'Exercice, GIP Exercice, Faculté de Médecine Lyon-Sud, BP 12, 69921 Oullins, France. laurent.messonnier@univ-lyon1.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology*
Exercise / physiology*
Female
Humans
Lactic Acid / blood*
Longitudinal Studies
Male
Oxygen
Oxygen Consumption
Partial Pressure
Physical Education and Training*
Physical Endurance
Reference Values
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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