| Blood lactate and ammonium ion accumulation during graded exercise in humans. | |
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MedLine Citation:
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PMID: 6469774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the pattern of blood lactate and ammonium ion (NH+4) accumulation during graded exercise in humans. Six adult volunteers performed a maximum O2 uptake (VO2 max) test on a bicycle ergometer. Blood samples were collected each minute of the test. Both blood lactate (r = 0.92) and NH4+ (r = 0.70) increased exponentially in relation to increased work. However, closer examination of individual curves revealed that both metabolites remained near resting levels during mild exercise (less than 40% VO2 max) and then demonstrated abrupt upward break points at increased work loads (greater than 50% VO2 max). There was a significant linear relationship (r = 0.96) between the work load at which the lactate break point (LBP) and NH4+ break point (ABP) occurred in each subject. In addition, there was a significant linear relationship (r = 0.82) between the blood concentrations of NH4+ and lactate during exercise. The results suggest a connection between NH4+ production and glycolytic energy metabolism during exercise. Several possible explanations are offered; however, further work at the cellular level is needed before the exact relationship between NH4+ and lactate can be determined. |
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Authors:
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M J Buono; T R Clancy; J R Cook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 57 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-09-24 Completed Date: 1984-09-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cations, Monovalent Energy Metabolism Exercise Test Female Humans Lactates / blood* Male Physical Exertion* Quaternary Ammonium Compounds / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cations, Monovalent; 0/Lactates; 0/Quaternary Ammonium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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