Document Detail


Blood lactate and ammonium ion accumulation during graded exercise in humans.
MedLine Citation:
PMID:  6469774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the pattern of blood lactate and ammonium ion (NH+4) accumulation during graded exercise in humans. Six adult volunteers performed a maximum O2 uptake (VO2 max) test on a bicycle ergometer. Blood samples were collected each minute of the test. Both blood lactate (r = 0.92) and NH4+ (r = 0.70) increased exponentially in relation to increased work. However, closer examination of individual curves revealed that both metabolites remained near resting levels during mild exercise (less than 40% VO2 max) and then demonstrated abrupt upward break points at increased work loads (greater than 50% VO2 max). There was a significant linear relationship (r = 0.96) between the work load at which the lactate break point (LBP) and NH4+ break point (ABP) occurred in each subject. In addition, there was a significant linear relationship (r = 0.82) between the blood concentrations of NH4+ and lactate during exercise. The results suggest a connection between NH4+ production and glycolytic energy metabolism during exercise. Several possible explanations are offered; however, further work at the cellular level is needed before the exact relationship between NH4+ and lactate can be determined.
Authors:
M J Buono; T R Clancy; J R Cook
Related Documents :
8300264 - Transcutaneous pco2-monitoring for the evaluation of the anaerobic threshold. compariso...
15586354 - Lactate transport and transporters: general principles and functional roles in brain ce...
23272664 - Aerobic exercise training improves right- and left ventricular systolic function in pat...
10735244 - The microbial association of greek taverna sausage stored at 4 and 10 degrees c in air,...
10484594 - Metabolic and performance responses to constant-load vs. variable-intensity exercise in...
10699094 - The effect of fatigue on multifinger co-ordination in force production tasks in humans.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  57     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-24     Completed Date:  1984-09-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cations, Monovalent
Energy Metabolism
Exercise Test
Female
Humans
Lactates / blood*
Male
Physical Exertion*
Quaternary Ammonium Compounds / blood*
Chemical
Reg. No./Substance:
0/Cations, Monovalent; 0/Lactates; 0/Quaternary Ammonium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bubble formation in crabs induced by limb motions after decompression.
Next Document:  Induction of airway collapse with subatmospheric pressure in awake patients with sleep apnea.