Document Detail

Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats.
MedLine Citation:
PMID:  11903418     Owner:  NLM     Status:  MEDLINE    
AIM: The objective of this study was to assess in rats the antidiabetic effects (i.e. reduction of hyperglycaemia and hypertriglyceridaemia) of trans-dehydrocrotonin (t-DCTN), a bioactive diterpene isolated from the popular medicinal plant Croton cajucara. METHODS: Hyperglycaemia was induced by intraperitoneal injection of streptozotocin (STZ) and hypertriglyceridaemia by oral administration of ethanol in rats. The blood glucose levels were measured by the glucose oxidase method using commercially available enzyme kits. RESULTS: Treating rats with t-DCTN (50 mg/kg) significantly reduced STZ-induced increases in blood glucose levels as well as ethanol-induced increases in blood triglycerides. CONCLUSION: The results suggest that t-DCTN has an antidiabetic potential that warrants further research on its mechanism and clinical significance.
R M Silva; F A Santos; V S Rao; M A Maciel; A C Pinto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  3     ISSN:  1462-8902     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-05-10     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-6     Citation Subset:  IM    
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
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MeSH Terms
Blood Glucose / drug effects,  metabolism*
Cholesterol / blood
Diabetes Mellitus, Experimental / drug therapy*
Diterpenes / isolation & purification,  therapeutic use*
Diterpenes, Clerodane*
Hyperglycemia / chemically induced,  drug therapy
Hypertriglyceridemia / blood,  drug therapy
Hypoglycemic Agents / therapeutic use*
Rats, Wistar
Reference Values
Triglycerides / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Diterpenes; 0/Diterpenes, Clerodane; 0/Hypoglycemic Agents; 0/Triglycerides; 0/dehydrocrotonin; 18883-66-4/Streptozocin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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