| Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats. | |
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MedLine Citation:
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PMID: 11903418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The objective of this study was to assess in rats the antidiabetic effects (i.e. reduction of hyperglycaemia and hypertriglyceridaemia) of trans-dehydrocrotonin (t-DCTN), a bioactive diterpene isolated from the popular medicinal plant Croton cajucara. METHODS: Hyperglycaemia was induced by intraperitoneal injection of streptozotocin (STZ) and hypertriglyceridaemia by oral administration of ethanol in rats. The blood glucose levels were measured by the glucose oxidase method using commercially available enzyme kits. RESULTS: Treating rats with t-DCTN (50 mg/kg) significantly reduced STZ-induced increases in blood glucose levels as well as ethanol-induced increases in blood triglycerides. CONCLUSION: The results suggest that t-DCTN has an antidiabetic potential that warrants further research on its mechanism and clinical significance. |
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Authors:
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R M Silva; F A Santos; V S Rao; M A Maciel; A C Pinto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: 3 ISSN: 1462-8902 ISO Abbreviation: Diabetes Obes Metab Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-03-20 Completed Date: 2002-05-10 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: England |
Other Details:
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Languages: eng Pagination: 452-6 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / drug effects, metabolism* Cholesterol / blood Croton Diabetes Mellitus, Experimental / drug therapy* Diterpenes / isolation & purification, therapeutic use* Diterpenes, Clerodane* Hyperglycemia / chemically induced, drug therapy Hypertriglyceridemia / blood, drug therapy Hypoglycemic Agents / therapeutic use* Male Phytotherapy* Rats Rats, Wistar Reference Values Streptozocin Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Diterpenes; 0/Diterpenes, Clerodane; 0/Hypoglycemic Agents; 0/Triglycerides; 0/dehydrocrotonin; 18883-66-4/Streptozocin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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