| Blood glucose and subsequent cardiovascular disease: update of a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 21973198 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background/purpose: A 1999 meta-analysis described the relationship between blood glucose and subsequent cardiovascular events (MI, stroke, cardiovascular mortality). More studies have been published; therefore, we updated and refined estimates of this relationship in people without diabetes. Acceptability criteria: We accepted prospective studies that reported screening results for blood glucose levels (either fasting, 2-hour postprandial, 1-hour postprandial, or casual) divided into ≥3 quantiles. Required data within each quantile were numbers exposed plus study duration or person-years at risk, and numbers of cardiovascular outcomes (myocardial infarction, stroke, death). No restrictions were placed on language or publication date. Data sources: Two reviewers searched Medline, Embase, Scopus, and Cochrane databases from inception until December 2009. Consensus settled discrepancies. Data synthesis: Poisson regression quantified the relationship between glucose quantile and outcomes. Beta values were combined with inverse variance weightings using a random effects meta-analytic model. Results: We found 36 articles with 141 datasets examining the relationship between blood glucose (32 fasting, 52 2-hour postprandial, 37 1-hour postprandial, 20 casual) in 191,249 patients without diabetes (73% male) for 3 million person-years. There were 12,537 (6.6%) cardiovascular deaths, 14,445 (7.6%) cardiovascular events, 6862 (3.6%) cardiac and 3412 (1.7%) stroke deaths. Relative risks/unit increase in blood glucose were all significant for total cardiovascular events (RRs ranged from 1.09-1.51, all p-values < 0.005) and cardiovascular deaths (RR = 1.05-1.24, p < 0.007), and all for cardiac deaths (p < 0.05) except casual glucose; stroke mortality was less clear. The two strongest relationships were found between fasting levels and all events (RR = 1.51, CI: 1.20-1.89) and with cardiovascular mortality (RR = 1.40, CI: 1.18-1.60). With 2-hour postprandial levels, the respective RRs were 1.22 (1.17-1.28) and 1.24 (1.19-1.30). A limitation is the assumption of a continuous relationship between variables. Conclusions: We have provided refined estimates confirming the association between elevated blood glucose and subsequent cardiovascular events. |
| | |
Authors:
|
Thomas R Einarson; Márcio Machado; Michiel Eric Henk Hemels |
Related Documents
:
|
6331498 - Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects. 6248408 - Improved glucose tolerance four hours after taking guar with glucose. 7025888 - Guar bread: acceptability and efficacy combined. studies on blood glucose, serum insuli... 2351868 - Effects of glucose ingestion on postprandial lipemia and triglyceride clearance in humans. 18759958 - A review of low and reduced carbohydrate diets and weight loss in type 2 diabetes. 17327378 - Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11be... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
|
Title: Current medical research and opinion Volume: - ISSN: 1473-4877 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Leslie Dan Faculty of Pharmacy, University of Toronto , ON , Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Density Functional Theory Studies on the Structures and Water-exchange Reactions of Aqueous Al(III)-...
Next Document: Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high risk patients w...