Document Detail

Blood glucose responses to reductions in pre-exercise rapid-acting insulin for 24 h after running in individuals with type 1 diabetes.
MedLine Citation:
PMID:  20496226     Owner:  NLM     Status:  MEDLINE    
In this study, we examined pre-exercise insulin reductions on consequent metabolic and dietary patterns for 24 h after running in individuals with type 1 diabetes. Seven participants self-administered their Full rapid-acting insulin dose or 75%, 50% or 25% of it, immediately before consuming a 1.12-MJ meal. After 2 h, participants completed 45 min of running at 70% peak oxygen uptake ([Vdot]O(2peak)). Blood glucose and insulin were measured for 2 h before and 3 h after exercise. Blood glucose, diet, and administered insulin were self-recorded for 24 h after exercise. Data were analysed using repeated-measures analysis of variance. Pre-exercise peak insulin concentrations were greatest with the Full dose and consequently elicited the lowest blood glucose concentrations (P < 0.05). Blood glucose decreased under all conditions with exercise, with the fall with the Full dose (-6.1 mmol . l(-1), s(x) = 0.4) greater than with 25% insulin (-3.2 mmol . l(-1), s(x) = 0.4; P < 0.05). There was little change in blood glucose from 0 to 3 h post-exercise under all conditions (P > 0.05). Blood glucose at 3 h post-exercise was greatest with the 25% dose. Over the next 21 h, blood glucose area under the curve was greater with the 25% dose compared with all other trials despite consuming less energy and fewer carbohydrates (P < 0.05). A 75% reduction to pre-exercise insulin results in the greatest preservation of blood glucose, and a reduced dietary intake, for 24 h after running in individuals with type 1 diabetes.
Daniel J West; Richard D Morton; Stephen C Bain; Jeffrey W Stephens; Richard M Bracken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of sports sciences     Volume:  28     ISSN:  1466-447X     ISO Abbreviation:  J Sports Sci     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-8     Citation Subset:  IM    
Sports and Exercise Science Research Centre, Swansea University, Swansea CH-9014, UK.
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MeSH Terms
Blood Glucose / drug effects,  physiology*
Body Mass Index
Diabetes Mellitus, Type 1 / metabolism*
Dietary Carbohydrates / administration & dosage,  metabolism
Heart Rate / physiology
Insulin / administration & dosage*,  blood
Oxygen Consumption / physiology
Running / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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