| Blood glucose responses to reductions in pre-exercise rapid-acting insulin for 24 h after running in individuals with type 1 diabetes. | |
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MedLine Citation:
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PMID: 20496226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we examined pre-exercise insulin reductions on consequent metabolic and dietary patterns for 24 h after running in individuals with type 1 diabetes. Seven participants self-administered their Full rapid-acting insulin dose or 75%, 50% or 25% of it, immediately before consuming a 1.12-MJ meal. After 2 h, participants completed 45 min of running at 70% peak oxygen uptake ([Vdot]O(2peak)). Blood glucose and insulin were measured for 2 h before and 3 h after exercise. Blood glucose, diet, and administered insulin were self-recorded for 24 h after exercise. Data were analysed using repeated-measures analysis of variance. Pre-exercise peak insulin concentrations were greatest with the Full dose and consequently elicited the lowest blood glucose concentrations (P < 0.05). Blood glucose decreased under all conditions with exercise, with the fall with the Full dose (-6.1 mmol . l(-1), s(x) = 0.4) greater than with 25% insulin (-3.2 mmol . l(-1), s(x) = 0.4; P < 0.05). There was little change in blood glucose from 0 to 3 h post-exercise under all conditions (P > 0.05). Blood glucose at 3 h post-exercise was greatest with the 25% dose. Over the next 21 h, blood glucose area under the curve was greater with the 25% dose compared with all other trials despite consuming less energy and fewer carbohydrates (P < 0.05). A 75% reduction to pre-exercise insulin results in the greatest preservation of blood glucose, and a reduced dietary intake, for 24 h after running in individuals with type 1 diabetes. |
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Authors:
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Daniel J West; Richard D Morton; Stephen C Bain; Jeffrey W Stephens; Richard M Bracken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of sports sciences Volume: 28 ISSN: 1466-447X ISO Abbreviation: J Sports Sci Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405364 Medline TA: J Sports Sci Country: England |
Other Details:
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Languages: eng Pagination: 781-8 Citation Subset: IM |
Affiliation:
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Sports and Exercise Science Research Centre, Swansea University, Swansea CH-9014, UK. 328181@swansea.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / drug effects, physiology* Body Mass Index Diabetes Mellitus, Type 1 / metabolism* Diet Dietary Carbohydrates / administration & dosage, metabolism Female Heart Rate / physiology Humans Insulin / administration & dosage*, blood Male Oxygen Consumption / physiology Running / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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