| Blood glucose level in neurosurgery. Is it different between isoflurane and desflurane anesthesia? | |
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MedLine Citation:
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PMID: 19752483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: A tight control of blood glucose is critical. We compare blood glucose level between isoflurane and desflurane in neurosurgical patients for further application. METHODS: One hundred and eight patients scheduled for neurosurgery under general anesthesia were recruited and divided into two groups; fentanyl-isoflurane-nitrous oxide based and fentanyl-desflurane-nitrous oxide based randomly. Vital signs, end tidal gas concentration, amount of narcotics usage and blood glucose level were recorded at induction (T0) and intraoperative hourly thereafter (T1-T8). Independent t-test and ANOVA were used. The statistical significance was considered if p-value < 0.05. RESULTS: There were 107 patients enrolled excluded one from isoflurane group because of the schedule changes. The amounts of fentanyl usage (0.89+/-0.41 mcg/kg/hr, 0.88+/-0.48 mcg/kg/hr), the end tidal inhales' tension (0.71%+/-0.32, 3.13%+/-1.63) were equivalent in isoflurane and desflurane group. The blood glucose levels at various period of time had no statistical difference but there was a significant (p<0.05) increasing from T1 to T8 comparing to T0 in both groups (3.88+/-0.93 mg%/hr and 5.55+/-1.14 mg%/hr). CONCLUSION: Desflurane has demonstrated the indistinguishable blood glucose level and hemodynamic response from isoflurane anesthesia intraoperatively in neurosurgical patients, confirming a comparable pattern of blood glucose concentration intensifying over time spends. |
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Authors:
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Phuping Akavipat; Nutchanun Polsayom; Songwut Pannak; Walaiporn Punkla |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta medica Indonesiana Volume: 41 ISSN: 0125-9326 ISO Abbreviation: Acta Med Indones Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-09-15 Completed Date: 2010-06-08 Revised Date: 2010-08-04 |
Medline Journal Info:
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Nlm Unique ID: 7901042 Medline TA: Acta Med Indones Country: Indonesia |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Prasat Neurological Institute, Bangkok 10400, Thailand. ppakvp@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anesthesia, Inhalation / methods* Anesthetics, Inhalation / administration & dosage* Blood Glucose / analysis* Female Humans Hyperglycemia / prevention & control Intraoperative Complications / prevention & control Isoflurane / administration & dosage*, analogs & derivatives* Male Middle Aged Monitoring, Intraoperative / methods* Nervous System Diseases / blood, surgery Neuroprotective Agents Neurosurgical Procedures* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Blood Glucose; 0/Neuroprotective Agents; 26675-46-7/Isoflurane; 57041-67-5/desflurane |
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