Document Detail


Blood gas changes and hypophosphatemia in lactate-induced panic.
MedLine Citation:
PMID:  3094475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alkalosis is prominent among the many physiologic and biochemical effects of sodium lactate infusion. Though this is partially due to the conversion of lactate to bicarbonate, the metabolic component, it may also be secondary to hyperventilation before and during the infusion, the respiratory component. We analyzed pH, carbon dioxide pressure, bicarbonate, and inorganic phosphate from patients with panic disorder and agoraphobia with panic attacks and from normal controls both before and during lactate infusion. Our findings extend earlier work demonstrating that many such patients are chronic hyperventilators. Both metabolic and respiratory alkalosis develop in all subjects during lactate infusion, but only hyperventilation-induced hypocapnia differentiates patients at the point of lactate-induced panic from nonpanicking patients and normal controls. Finally, low inorganic phosphate levels at baseline appear associated with patients who will panic during the subsequent lactate infusion. This last unexpected finding may reflect hyperventilation or an abnormality in intracellular glycolysis.
Authors:
J M Gorman; B S Cohen; M R Liebowitz; A J Fyer; D Ross; S O Davies; D F Klein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  43     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1067-71     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkalosis / etiology*
Alkalosis, Respiratory / etiology
Anxiety Disorders / blood,  chemically induced*
Carbon Dioxide / blood
Fear*
Female
Humans
Hyperventilation / complications
Lactates* / administration & dosage,  metabolism
Lactic Acid
Male
Middle Aged
Oxygen / blood
Panic*
Phosphates / blood*
Grant Support
ID/Acronym/Agency:
MH 903-1163C/MH/NIMH NIH HHS; MH-00416/MH/NIMH NIH HHS; MHCR 903-C006/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Lactates; 0/Phosphates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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