Document Detail


Blood flow to oral tissues: and experimental study with enflurane, sodium nitroprusside, and nitroglycerin.
MedLine Citation:
PMID:  6801227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypotensive anesthesia is currently being used in oral and maxillofacial surgery to reduce blood loss and provide a relatively bloodless surgical field. Radioactively labeled microspheres were used to determine and compare the hemodynamic effects of sodium nitroprusside (SNP), nitroglycerin (NTG), and deep enflurane anesthesia on oral tissues during controlled hypotension when compared with controls. Sodium nitroprusside and NTG produced significant reductions in blood flow to the maxilla, mandible, and tongue, while deep enflurane anesthesia did not. In the masseter and suprahyoid muscles, increases in tissue blood flow were found with SNP and enflurane. Nitroglycerin produced no significant change in blood flow in the masseter and the suprahyoid. These results demonstrate that in spite of a similar cardiac index with all agents tested, local oral blood flow varied significantly with the different agents tested. These differences in tissue blood flow suggest that SNP and NTG may be preferable to deep enflurane anesthesia for maxillary osteotomies to achieve greater flow reduction and diminish blood loss.
Authors:
S Bergman; W E Hoffman; B J Gans; D J Miletich; R F Albrecht
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  40     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation
Animals
Enflurane / pharmacology*
Female
Ferricyanides / pharmacology*
Hypotension, Controlled
Mouth / blood supply*,  surgery
Nitroglycerin / pharmacology*
Nitroprusside / pharmacology*
Rats
Rats, Inbred Strains
Regional Blood Flow / drug effects
Grant Support
ID/Acronym/Agency:
HL25399/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ferricyanides; 13838-16-9/Enflurane; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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