| Blood flow through new microvessels: factors that affect regrowth of vasa vasorum. | |
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MedLine Citation:
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PMID: 2447803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A segment of abdominal aorta in dogs was transplanted to its original position (high PO2) or to the femoral vein (low PO2), and a segment of thoracic aorta was transplanted to its original position. Two days after grafting to each location, there was no blood flow (measured with microspheres) through vasa vasorum. After 2 and 4 wk, blood flow through vasa was restored to normal, or above normal, levels in all grafts. Vasa in grafts did not have smooth muscle, and they were not responsive to adenosine. Medial necrosis occurred in grafts of thoracic aorta but not in grafts of abdominal aorta. There was cellular degeneration and medial atrophy in grafts of abdominal aorta to the femoral vein. We conclude that 1) revascularization of the aorta by vasa vasorum is rapid; 2) new vasa do not have smooth muscle, and they are not responsive to vasoactive stimuli; and 3) medial necrosis occurs in grafts in which delivery of oxygen to media is compromised, either by low luminal PO2 or by interruption of medial vasa (in thoracic aorta), but not when the abdominal aorta is excised and reanastomosed. Absence of medial necrosis in grafts of abdominal aorta indicates that diffusion from the lumen of the vessel is adequate to nourish the vessel. This finding provides evidence that adventitial vasa, in contrast to medial vasa, are not essential for nourishment of the vessel wall. |
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Authors:
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J K Williams; M L Armstrong; D D Heistad |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 254 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-02-25 Completed Date: 1988-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H126-32 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Animals Aorta, Abdominal / transplantation Aorta, Thoracic / physiology*, transplantation Blood Volume / drug effects Dogs Microcirculation Microspheres Neovascularization, Pathologic / physiopathology* Regeneration Vasa Vasorum / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-07371/HL/NHLBI NIH HHS; HL-14230/HL/NHLBI NIH HHS; HL-14388/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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