| Blood flow quantification of the human retina with MRI. | |
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MedLine Citation:
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PMID: 20862658 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the feasibility of measuring blood flow to the retina using arterial spin labeling MRI, a quantitative, noninvasive tomographic technique. Blood flow imaging was performed in a single axial slice through both eyes of five healthy volunteers with no history of retinal diseases. The imaging was optimized to minimize the errors from motion and nonuniform magnetic fields caused by proximity to the sinuses. Key hemodynamic factors for flow quantification, including arterial transit delay and the apparent decay time of the signal, were estimated by repeated measurements with different arterial spin labeling timing. A clearly elevated signal, consistent with the anatomical location of the retina, was observed in all subjects. The measured blood flow to a 1 cm × 1.47 cm section of the retina, centered on the fovea, was 1.75 ± 0.54 µL/mm(2) /min (total blood flow of 261 ± 87 µL/min). The arterial transit delay from a labeling plane 5 cm below the slice was 1137 ± 288 ms. These results establish the feasibility of measuring blood flow to the retina with MRI, and support the future characterization of the healthy and diseased ocular circulation with this method. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Nasim Maleki; Weiying Dai; David C Alsop |
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Publication Detail:
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Type: Journal Article Date: 2010-09-22 |
Journal Detail:
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Title: NMR in biomedicine Volume: 24 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 104-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA USA. nmaleki@mclean.harvard.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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