| Blood flow in the skin of type 1 diabetic patients before and after combined pancreas/kidney transplantation. | |
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MedLine Citation:
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PMID: 15880479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To analyze effects of long-term glucose normalization after pancreas transplantation, different parameters of skin microcirculation were assessed by laser Doppler fluxmetry. METHODS: Forty-two type 1 diabetic patients after successful simultaneous pancreas/kidney transplantation (Group A, median 32.3 months posttransplant), 28 patients with functioning kidney grafts, but insulin therapy (Group B, median 64.9 months posttransplant) and 13 diabetic pretransplant patients (Group C, median 14.2 months on dialysis) were compared with 33 healthy subjects (Group D). Resting blood flow, postocclusive hyperemia, venoarteriolar response on the right foot and decrease in blood flow during cold pressure test on the left finger was assessed. RESULTS: Postocclusive hyperemia, decrease in blood flow during cold pressure test and venoarteriolar response were higher in Group D than in all patient groups. Resting blood flow in Group A was significantly lower than in Groups B and C (following values as median): 3.6 perfusion units (PU) versus 7.4 PU in Group B, p < 0.01 and 12.1 PU in Group C, p < 0.001, respectively, and was not significantly different to controls (Group D, 5.2 PU). Postocclusive hyperemia was higher in Group A than in Groups B and C (266.7% vs 160.0%, p < 0.05 and 79.4% n.s., respectively), but significantly less than in Group D (563.5%). The microangiopathy index-high values reflecting less or no microangiopathy-was significantly higher in Group A than in Groups B and C (11.0 vs 4.3, p < 0.001 and 4.7, p < 0.05, respectively), and was very much comparable to the values in healthy controls (Group D, 10,3). The decrease in blood flow during cold pressure test was higher in Group A compared to Groups B and C (25.2% vs 21.1% and 13.8%, n.s., respectively), but much less than in Group D (65,7%). CONCLUSION: These data suggest an improvement without complete normalization of skin microcirculation by long-term blood glucose normalization achieved by pancreas transplantation. |
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Authors:
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Nicola Eberl; Wolfgang Piehlmeier; Stefan Dachauer; August König; Walter Land; Rüdiger Landgraf |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: 21 ISSN: 1520-7552 ISO Abbreviation: Diabetes Metab. Res. Rev. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-10-26 Completed Date: 2006-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 525-32 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Internal Medicine Innenstadt, University of Munich, Germany. mediger.landgraf@med.uni-muenchen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cross-Sectional Studies Diabetes Mellitus, Type 1 / physiopathology*, surgery* Diabetic Angiopathies / physiopathology Female Fingers Foot Humans Insulin / therapeutic use Kidney Transplantation* / physiology Laser-Doppler Flowmetry Male Microcirculation / physiology Middle Aged Pancreas Transplantation* / physiology Regional Blood Flow* Skin / blood supply* Skin Temperature |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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