Document Detail

Blood flow in maxilla and mandible of normal and atherosclerotic rhesus monkeys.
MedLine Citation:
PMID:  3932619     Owner:  NLM     Status:  MEDLINE    
Atherosclerotic vascular disease affects many individuals, particularly in an elderly population. This study examined alterations in the vasculature and blood flow in the maxilla and mandible in rhesus monkeys fed an atherogenic (high fat) diet. No significant difference was found in blood flow between different regions of the bone (anterior mandible, posterior mandible and maxilla) in animals on either a normal or a high fat diet but overall blood flow in the monkeys on the atherogenic diet was significantly lower (p less than 0.001) than in the control group. Histologic examination of tissue from the animals fed an atherogenic diet revealed minimal changes within the intrabony vasculature and measurements of these vessels showed no significant difference in the percentage of tissue occupied by vessel lumina or in average wall thickness between the groups of animals. On the other hand, tissue from the tongue exhibited gross atherosclerotic vascular lesions and examination of the carotid arteries revealed not only intimal plaques but extensive calcification. It thus appears that the decreased flow measured in the maxilla and mandible may be related to the severely involved afferent vessels rather than to functional changes in the local vasculature.
C V Brenneise; C A Squier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of oral pathology     Volume:  14     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-19     Completed Date:  1985-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  800-8     Citation Subset:  D; IM    
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MeSH Terms
Arteriosclerosis / pathology,  physiopathology*
Blood Vessels / pathology
Diet, Atherogenic
Macaca mulatta
Mandible / blood supply*
Maxilla / blood supply*
Regional Blood Flow
Grant Support
14230//PHS HHS; S07-RRO5313-21/RR/NCRR NIH HHS

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