Document Detail

Blood flow in experimental liver tumors: effect of vasoactive drugs.
MedLine Citation:
PMID:  7468035     Owner:  NLM     Status:  MEDLINE    
The effects of infused glucagon, histamine and vasopressin on blood flow in anaesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induce a decrease in hepatic and pulmonary blood flow Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood flow in relation to surrounding liver tissue blood flow was registered after infusion of vasopressin. No effects were seen after glucagon or histamine infusion.
L Hafström; B Persson; K Sundqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  146     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / blood supply
Glucagon / pharmacology*
Hemodynamics / drug effects
Histamine / pharmacology*
Liver Neoplasms / blood supply*,  physiopathology
Liver Neoplasms, Experimental / blood supply
Neoplasms, Experimental / blood supply,  physiopathology
Regional Blood Flow / drug effects
Vasopressins / pharmacology*
Reg. No./Substance:
11000-17-2/Vasopressins; 51-45-6/Histamine; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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