| Blood flow in the atrophied pancreas. | |
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MedLine Citation:
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PMID: 2188848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic and islet blood flow was measured by quantitative determination of microspheres within atrophied pancreases of rats rendered dietarily copper-deficient. The deficient state effects selective acinar necrosis and its replacement with non-inflammatory lipomatosis. While blood flow to lipomatous glands remained intact, it was significantly less (0.41 +/- 0.02 ml/min X g pancreas) compared to normal control glands (0.50 +/- 0.01 ml/min X g pancreas). Blood flow to islets, which remain unaffected by selective acinar atrophy of the copper-deficient state, was not significantly altered (50.8 +/- 2.13 microliters/min X g pancreas) compared to controls (55.7 +/- 2.66 microliters/min X g pancreas). The percent of islet blood flow (IBF) within atrophied glands (12.2 +/- 0.31) was found to be significantly greater than control glands (10.7 +/- 0.21). It is suggested that the maintenance of IBF and IBF percentage in the atrophic pancreas may reflect the parallel arrangement of islet angioarchitecture which based on morphological data is not appreciably altered with attenuation of acinar plexuses. Microspheres, although not quantitated, were also found distributed within the adventitia of ducts as well as in vessels supplying intrapancreatic nerves and ganglia which remain intact in copper deficiency-induced acinar atrophy. |
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Authors:
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F C Weaver |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental pathology Volume: 38 ISSN: 0232-1513 ISO Abbreviation: Exp Pathol Publication Date: 1990 |
Date Detail:
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Created Date: 1990-07-05 Completed Date: 1990-07-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8108218 Medline TA: Exp Pathol Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 119-27 Citation Subset: IM |
Affiliation:
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Department of Biology, Saint John's University, Collegeville, MN 56321. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrophy Islets of Langerhans / blood supply*, pathology Microscopy, Fluorescence Pancreas / blood supply*, pathology Rats Rats, Inbred Strains Regional Blood Flow |
| Grant Support | |
ID/Acronym/Agency:
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5 RO1 DK36745/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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