Document Detail


Blood flow in the atrophied pancreas.
MedLine Citation:
PMID:  2188848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pancreatic and islet blood flow was measured by quantitative determination of microspheres within atrophied pancreases of rats rendered dietarily copper-deficient. The deficient state effects selective acinar necrosis and its replacement with non-inflammatory lipomatosis. While blood flow to lipomatous glands remained intact, it was significantly less (0.41 +/- 0.02 ml/min X g pancreas) compared to normal control glands (0.50 +/- 0.01 ml/min X g pancreas). Blood flow to islets, which remain unaffected by selective acinar atrophy of the copper-deficient state, was not significantly altered (50.8 +/- 2.13 microliters/min X g pancreas) compared to controls (55.7 +/- 2.66 microliters/min X g pancreas). The percent of islet blood flow (IBF) within atrophied glands (12.2 +/- 0.31) was found to be significantly greater than control glands (10.7 +/- 0.21). It is suggested that the maintenance of IBF and IBF percentage in the atrophic pancreas may reflect the parallel arrangement of islet angioarchitecture which based on morphological data is not appreciably altered with attenuation of acinar plexuses. Microspheres, although not quantitated, were also found distributed within the adventitia of ducts as well as in vessels supplying intrapancreatic nerves and ganglia which remain intact in copper deficiency-induced acinar atrophy.
Authors:
F C Weaver
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental pathology     Volume:  38     ISSN:  0232-1513     ISO Abbreviation:  Exp Pathol     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8108218     Medline TA:  Exp Pathol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Affiliation:
Department of Biology, Saint John's University, Collegeville, MN 56321.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Islets of Langerhans / blood supply*,  pathology
Microscopy, Fluorescence
Pancreas / blood supply*,  pathology
Rats
Rats, Inbred Strains
Regional Blood Flow
Grant Support
ID/Acronym/Agency:
5 RO1 DK36745/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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