| Blood flow changes in hepatocellular carcinoma after the administration of thalidomide assessed by reperfusion kinetics during microbubble infusion: preliminary results. | |
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MedLine Citation:
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PMID: 16355035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate whether thalidomide is able to produce tumor vascular changes in patients with untreatable hepatocellular carcinoma (HCC) that can be detected using microbubble contrast agents. MATERIALS AND METHODS: Eleven consecutive patients with untreatable HCC underwent contrast-enhanced ultrasound before and during thalidomide administration. Real-time destruction reperfusion kinetics was obtained from a representative HCC nodule and from the surrounding liver parenchyma during SonoVue infusion (Bracco, Milan, Italy) at a constant rate of 0.10 mL/s by using a syringe pump and modelized according to the mathematical function SI = A(1 - exp(-betat)) where the plateau signal intensity A reflects the percent blood volume, the time constant beta reflects the average speed of blood, and their product A*beta reflects the nutrient blood flow. RESULTS: Size of the representative nodule reduced significantly 3 to 6 months after the start of thalidomide treatment. Before thalidomide administration A, beta, and A*beta of the index lesion were 44 +/- 60 LIU, 0.31 +/- 0.40 seconds and 8.1 +/- 11.8 LIU/s, respectively). A and A*beta reduced significantly after 15 days (26 +/- 50 LIU and 2.9 +/- 4.8 LIU/s, P < 0.01), 3 months (12 +/- 18 LIU, and 4.3 +/- 7.7 LIU/s, P < 0.01), and 6 months (13 +/- 23 LIU and 2.4 +/- 3.7 LIU/s, P < 0.05) of treatment. No statistically significant changes of the exponential time constant beta were observed, nor changes of A, beta and A*beta in the liver parenchyma. CONCLUSIONS: Contrast-enhanced ultrasound can be used effectively to evaluate changes in perfusion parameters of HCC nodules during thalidomide administration. |
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Authors:
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Michele Bertolotto; Gabriele Pozzato; Lory Saveria Crocè; Fabiana Nascimben; Cristiana Gasparini; Maria Assunta Cova; Claudio Tiribelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 41 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-15 Completed Date: 2006-03-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
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UCO di Radiologia, Università di Trieste, Ospedale di Cattinara, Italy. bertolot@units.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiogenesis Inhibitors / therapeutic use* Carcinoma, Hepatocellular / drug therapy*, ultrasonography Contrast Media Female Humans Image Processing, Computer-Assisted Liver Neoplasms / drug therapy*, ultrasonography Male Microbubbles Middle Aged Neovascularization, Pathologic / drug therapy* Phospholipids / diagnostic use Statistics, Nonparametric Sulfur Hexafluoride / diagnostic use Survival Analysis Thalidomide / therapeutic use* Treatment Outcome Ultrasonography, Interventional* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride; 50-35-1/Thalidomide |
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