| Blood flow and cell-free layer in microvessels. | |
| | |
MedLine Citation:
|
PMID: 21044216 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Blood is modeled as a suspension of red blood cells using the dissipative particle dynamics method. The red blood cell membrane is coarse-grained for efficient simulations of multiple cells, yet accurately describes its viscoelastic properties. Blood flow in microtubes ranging from 10 to 40 μm in diameter is simulated in three dimensions for values of hematocrit in the range of 0.15-0.45 and carefully compared with available experimental data. Velocity profiles for different hematocrit values show an increase in bluntness with an increase in hematocrit. Red blood cell center-of-mass distributions demonstrate cell migration away from the wall to the tube center. This results in the formation of a cell-free layer next to the tube wall corresponding to the experimentally observed Fahraeus and Fahraeus-Lindqvist effects. The predicted cell-free layer widths are in agreement with those found in in vitro experiments; the results are also in qualitative agreement with in vivo experiments. However, additional features have to be taken into account for simulating microvascular flow, e.g., the endothelial glycocalyx. The developed model is able to capture blood flow properties and provides a computational framework at the mesoscopic level for obtaining realistic predictions of blood flow in microcirculation under normal and pathological conditions. |
| | |
Authors:
|
Dmitry A Fedosov; Bruce Caswell; Aleksander S Popel; George Em Karniadakis |
Related Documents
:
|
2916616 - An evaluation of red blood cell heterogeneity (increased red blood cell distribution wi... 1005126 - Efficiency of in vivo labeling of red blood cells with 99mtc. 15239856 - Quantitation of fluoride ion released sarin in red blood cell samples by gas chromatogr... 9609536 - Rheological properties and function of blood cells in stored bank blood and salvaged bl... 3812556 - Paternity testing 3: exclusion probabilities. 14096 - Causes of high blood o2 affinity of animals living at high altitude. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Microcirculation (New York, N.Y. : 1994) Volume: 17 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
|
Languages: eng Pagination: 615-28 Citation Subset: IM |
Copyright Information:
|
© 2010 John Wiley & Sons Ltd. |
Affiliation:
|
Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R01HL094270/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between maternal arterial wave reflection, microvascular function and fetal growth in n...
Next Document: Development of an image-based system for measurement of membrane potential, intracellular ca(2+) and...