| Blood flow analysis of compressed nerve root after intravenous injection of lipo-prostaglandin E1. | |
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MedLine Citation:
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PMID: 19322792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin E(1) (PGE(1)) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE(1) is effective in some patients but not in others, although the reason for this is unclear. The aim of the present study was to measure changes in intraradicular blood flow after intravenous injection of lipo-PGE(1) (0.15 microg/kg) using a laser Doppler flow meter in control model and nerve root compression model. Then, the nerve root in which blood flow was measured was removed and examined histologically. Intravenous injection of lipo-PGE(1) also resulted in marked increase of blood flow in the uncompressed nerve roots of the control group, but caused minimal enhancement of blood flow at the sites of nerve root compression exhibiting Wallerian degeneration. It is concluded that lipo-PGE(1) has less effect on markedly degenerated nerve roots than it does on those that are normal. |
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Authors:
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Shigeru Kobayashi; Hisatoshi Baba; Kenichi Takeno; Seiichro Shimada; Masafumi Kubota; Takafumi Yayama; Tsuyoshi Miyazaki; Kenzo Uchida; Yoshihiko Suzuki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 27 ISSN: 1554-527X ISO Abbreviation: J. Orthop. Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 1252-7 Citation Subset: IM |
Copyright Information:
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(c) 2009 Orthopaedic Research Society. |
Affiliation:
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Department of Orthopaedics and Rehabilitation Medicine Fukui, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan. kshigeru@u-fukui.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil
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pharmacology* Animals Blood Pressure / drug effects Disease Models, Animal Dogs Injections, Intravenous Laser-Doppler Flowmetry Lumbar Vertebrae Nerve Compression Syndromes / drug therapy*, pathology Regional Blood Flow / drug effects* Spinal Nerve Roots / blood supply*, pathology Spinal Stenosis / drug therapy, pathology Vasodilator Agents / pharmacology* Wallerian Degeneration / pathology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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