| Blood flow acceleration in the carotid and brachial arteries of healthy volunteers: respective contributions of cardiac performance and local resistance. | |
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MedLine Citation:
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PMID: 8871139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of local resistance and cardiac performance on peripheral blood acceleration was investigated in 14 healthy male volunteers. Steady and pulsatile flow was studied in the brachial and in the common carotid arteries, ie, two territories that exhibit marked differences in resistive characteristics. Instantaneous blood velocity (V), mean blood velocity (Vm) and artery diameter (D) were evaluated at rest by an ultrasonic range-gated pulsed Doppler flowmeter using a double transducer probe, thus allowing the calculation of mean blood flow (Q). Mean local resistance (R) was obtained by dividing the mean arterial pressure by Q. The peak value of the local acceleration of the blood was obtained by computer-assisted calculation of the first derivative of instantaneous blood velocity (Gmax = +dV/dtmax). Peak aortic blood acceleration (GAo) was simultaneously measured from the suprasternal notch using a pulsed Doppler velocity meter. In the branchial and the common carotid arteries, Gmax was of a similar magnitude (551 +/- 30 and 555 +/- 44 cm/s2, respectively) despite major differences in the respective D, Vm, Q and R values. In neither artery was there a relationship between Gmax and either resting Q or R. At the brachial artery level, Gmax was positively related to GAo (r = 0.79, P = 0.0008). At the common carotid artery level, there was a weak, although non significant relationship between Gmax and GAo (P = 0.08). Our results indicate that the local acceleration of peripheral blood flow in the brachial artery is related rather to upstream central impulse than to downstream hemodynamics, and suggest some regional differences in the hemodynamic determinants of the local acceleration of peripheral blood flow. |
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Authors:
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D Chemla; P Démolis; M Thyrault; D Annane; Y Lecarpentier; J F Giudicelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 10 ISSN: 0767-3981 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-03 Completed Date: 1997-01-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: FRANCE |
Other Details:
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Languages: eng Pagination: 393-9 Citation Subset: IM |
Affiliation:
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Inserm, U451-Ensta-Loa-Ecole Polytechnique, Palaiseau, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Blood Pressure Brachial Artery / physiology* Cardiac Output Carotid Artery, Common / physiology* Heart Rate Humans Laser-Doppler Flowmetry Male Regional Blood Flow Vascular Resistance* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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