Document Detail


Blood film features of sickle cell-haemoglobin C disease.
MedLine Citation:
PMID:  8485058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The blood films of patients with sickle cell-haemoglobin C disease (SC) were compared with those of patients with related haemoglobinopathies in order to establish the most characteristic features. The blood films from SC patients generally permitted the distinction from sickle cell anaemia (SS) but not necessarily from haemoglobin C disease (CC) or C/beta thalassaemia. About half of the SC films showed characteristic SC poikilocytes and a minority also had some cells containing haemoglobin C crystals. In addition, SC differed from SS in having fewer classical sickle cells and nucleated red cells, more irregularly-contracted cells and less polychromasia and evidence of hyposplenism.
Authors:
B J Bain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  83     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-07     Completed Date:  1993-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  516-8     Citation Subset:  IM    
Affiliation:
Department of Haematology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Sickle Cell / blood
Erythrocytes, Abnormal / pathology
Hemoglobin C Disease / blood
Hemoglobin SC Disease / blood*
Humans
beta-Thalassemia / blood

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