| Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma. | |
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MedLine Citation:
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PMID: 23347007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The inflammatory phenotypes of severe asthma in adults may be reflected in peripheral blood. If this were true in children with severe therapy-resistant asthma (STRA), invasive tests could be avoided. At the moment there is no conclusive evidence in children. METHODS: All patients underwent blood tests, exhaled nitric oxide (FeNO), sputum induction, bronchoalveolar lavage (BAL) and endobronchial biopsy (EB). RESULTS: Sixty-three (71.6%) patients had a normal blood profile and only 1/88 had a combined blood eosinophilia and neutrophilia. 76/88 (86%) had normal blood eosinophils, but of these, 84% had airway eosinophilia in either BAL (n = 43;66%) or EB (n = 41;79%). In children with STRA blood eosinophilia was associated with airway eosinophilia. However, normal blood eosinophil levels did not exclude airway eosinophilic inflammation. CONCLUSIONS: Peripheral blood counts are not reliable in characterising airway inflammation in severe asthmatic children exposed to high dose steroid therapy, therefore bronchoscopy with BAL should be considered. |
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Authors:
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N Ullmann; C J Bossley; L Fleming; M Silvestri; A Bush; S Saglani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-25 |
Journal Detail:
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Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: Allergy Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 John Wiley & Sons A/Sons A/S Published by Blackwell Publishing Ltd. |
Affiliation:
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Respiratory Paediatrics, Royal Brompton Hospital London and NHLI Imperial College London, London, UK; Respiratory Unit, Department of Paediatrics, Bambino Gesù Research Institute, Rome. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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