| Blood eosinophil counts for the prediction of the severity of exercise-induced bronchospasm in asthma. | |
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MedLine Citation:
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PMID: 11860169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that airway eosinophilic inflammation is associated with the severity of exercise-induced bronchospasm (EIB). Blood eosinophils are known to be an indirect marker of airway inflammation in asthma. The aim of this study is to investigate that a simple and easy blood test for blood eosinphil counts may predict the severity of EIB in asthma. Seventy-seven men with perennial asthma (age range 18-23 years) were included. Lung function test, skin prick test, and blood tests for eosinophils counts and total IgE levels were performed. Methacholine bronchial provocation test and, 24 h later, free running test were carried out. EIB was defined as a 15% reduction or more in post-exercise FEV1 compared with pre-exercise FEV1 value. Atopy score was defined as a sum of mean wheal diameters to allergens. EIB was observed in 60 (78%) of 77 subjects. Asthmatics with EIB showed significantly increased percentages of eosinophils (P<0.01), log eosinophil counts (P<0.001), and atopy scores (P<0.05) and decreased log PC20 values (P < 0.05) compared with asthmatics without EIB. Asthmatics with eosinophils of > 700 microl(-1) (36.9 +/- 12.7%) had significantly greater maximal % fall in FEV1 after exercise than asthmatics with eosinophils of < 350 microl(-1) (24.7 +/- 16.6%, P <0.05). Blood eosinophil counts > 350 microl(-1) yielded the specificity of 88% and positive predictive value of 93% for the presence of EIB. When a multiple regression analysis of maximal % fall in FEV1 according to log eosinophil counts, log PC20, log IgE and atopy score was performed, only blood eosinophil counts were significant factor contributing to the maximal % fall in FEV1 after exercise. These findings not only suggest that a simple blood test for eosinophils may be useful in the prediction of the severity of EIB, but also reinforce the view that airway eosinophilic inflammation may play a major role in EIB in asthma. |
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Authors:
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Y I Koh; S Choi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiratory medicine Volume: 96 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-25 Completed Date: 2002-03-13 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 120-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Kwangju, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asthma, Exercise-Induced / blood, physiopathology* Biological Markers / blood Bronchial Spasm / blood, diagnosis* Bronchoconstrictor Agents / diagnostic use Chi-Square Distribution Eosinophils / pathology* Exercise Test Humans Immunoglobulin E / blood Leukocyte Count Male Methacholine Chloride / diagnostic use Regression Analysis Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Bronchoconstrictor Agents; 37341-29-0/Immunoglobulin E; 62-51-1/Methacholine Chloride |
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