Document Detail

Blood eosinophil counts for the prediction of the severity of exercise-induced bronchospasm in asthma.
MedLine Citation:
PMID:  11860169     Owner:  NLM     Status:  MEDLINE    
It has been suggested that airway eosinophilic inflammation is associated with the severity of exercise-induced bronchospasm (EIB). Blood eosinophils are known to be an indirect marker of airway inflammation in asthma. The aim of this study is to investigate that a simple and easy blood test for blood eosinphil counts may predict the severity of EIB in asthma. Seventy-seven men with perennial asthma (age range 18-23 years) were included. Lung function test, skin prick test, and blood tests for eosinophils counts and total IgE levels were performed. Methacholine bronchial provocation test and, 24 h later, free running test were carried out. EIB was defined as a 15% reduction or more in post-exercise FEV1 compared with pre-exercise FEV1 value. Atopy score was defined as a sum of mean wheal diameters to allergens. EIB was observed in 60 (78%) of 77 subjects. Asthmatics with EIB showed significantly increased percentages of eosinophils (P<0.01), log eosinophil counts (P<0.001), and atopy scores (P<0.05) and decreased log PC20 values (P < 0.05) compared with asthmatics without EIB. Asthmatics with eosinophils of > 700 microl(-1) (36.9 +/- 12.7%) had significantly greater maximal % fall in FEV1 after exercise than asthmatics with eosinophils of < 350 microl(-1) (24.7 +/- 16.6%, P <0.05). Blood eosinophil counts > 350 microl(-1) yielded the specificity of 88% and positive predictive value of 93% for the presence of EIB. When a multiple regression analysis of maximal % fall in FEV1 according to log eosinophil counts, log PC20, log IgE and atopy score was performed, only blood eosinophil counts were significant factor contributing to the maximal % fall in FEV1 after exercise. These findings not only suggest that a simple blood test for eosinophils may be useful in the prediction of the severity of EIB, but also reinforce the view that airway eosinophilic inflammation may play a major role in EIB in asthma.
Y I Koh; S Choi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  96     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-03-13     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Kwangju, Korea.
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MeSH Terms
Asthma, Exercise-Induced / blood,  physiopathology*
Biological Markers / blood
Bronchial Spasm / blood,  diagnosis*
Bronchoconstrictor Agents / diagnostic use
Chi-Square Distribution
Eosinophils / pathology*
Exercise Test
Immunoglobulin E / blood
Leukocyte Count
Methacholine Chloride / diagnostic use
Regression Analysis
Skin Tests
Reg. No./Substance:
0/Biological Markers; 0/Bronchoconstrictor Agents; 37341-29-0/Immunoglobulin E; 62-51-1/Methacholine Chloride

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