Document Detail


Blood cytokines during the perinatal period in very preterm infants: relationship of inflammatory response and bronchopulmonary dysplasia.
MedLine Citation:
PMID:  18760808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the influence of chorioamnionitis (CA) on plasma cytokines and the cytokine-associated risk of bronchopulmonary dysplasia (BPD) during the perinatal period. STUDY DESIGN: Eleven cytokines from 128 very low gestational age infants were analyzed from cord blood and from plasma at ages 1 day and 7 days after birth. The diagnosis of CA was based on histology of the placenta, fetal membranes, and umbilical cord. Neonatal risk factors were recorded. RESULTS: In the 48 infants born with CA, high concentrations of inflammatory cytokines in cord blood decreased during the first postnatal day. Inflammatory cytokines in cord blood was associated with the severity of CA. At 1 day after birth, the concentration of interleukin (IL)-8 predicted the risk of BPD. For the 75 infants born without CA, cytokine concentrations increased after birth. For the 128 infants born with or without CA, at 1 day after birth, the concentrations of IL-8, granulocyte colony-stimulating factor, and anti-inflammatory IL-10 were associated with the risk of BPD, after adjustment for the duration of gestation and severity of respiratory distress during the first day. CONCLUSIONS: In infants exposed to CA, insufficient inhibition of high fetal inflammatory cytokine response shortly after birth may increase the risk of BPD.
Authors:
Reija Paananen; Anna-Karin Husa; Reetta Vuolteenaho; Riitta Herva; Tuula Kaukola; Mikko Hallman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-30
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-43.e3     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Oulu, Oulu, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bronchopulmonary Dysplasia / blood,  epidemiology*
Chorioamnionitis / blood*
Cytokines / blood*
Female
Fetal Blood / chemistry*
Humans
Infant, Newborn
Infant, Premature / blood*
Interleukin-10 / analysis
Interleukin-8 / analysis
Male
Pregnancy
Prospective Studies
ROC Curve
Risk Factors
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-8; 130068-27-8/Interleukin-10
Comments/Corrections
Comment In:
J Pediatr. 2009 Jan;154(1):A2   [PMID:  19187720 ]

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