Document Detail


Blood culture isolates and antimicrobial sensitivities from 427 critically ill neonatal foals.
MedLine Citation:
PMID:  18616477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assist correct decision-making about antimicrobial treatment of equine neonates with septicaemia. DESIGN: Retrospective study of microbial blood culture results obtained from foals less than 7 days of age. METHODS: Microbial blood culture results from foals less than 7 days of age admitted to an intensive care unit between July 1999 and December 2004 were reviewed. Antimicrobial sensitivity was assessed by the Kirby Bauer disc diffusion method. Antimicrobials were defined as an effective first-line choice antimicrobial if greater than 70% of isolates were susceptible. Multiple drug resistance (MDR) was defined as resistance to at least three antimicrobials in different chemical classes or with different mechanisms of resistance. RESULTS: Of the 427 Thoroughbred foals included in the study, a positive blood culture was obtained in 110 foals and 124 microorganisms were isolated. Gram-positive isolates, predominantly Streptococcus/Enterococcus spp, were obtained in 41% of foals. Gram-negative isolates were predominantly of the Enterobacteriaceae family, in particular Escherichia coli. The overall antimicrobial sensitivity of the isolates was low. The Gram-positive organisms had unpredictable sensitivity patterns. MDR was recorded in 32% of isolates. In total, 81% of foals were discharged from hospital and 74.5% of foals with a positive blood culture were discharged. CONCLUSION: With the increasing prevalence of Gram-positive microorganisms and their unpredictable sensitivity patterns, blood cultures remain important in the diagnosis and treatment of equine neonatal septicaemia.
Authors:
C M Russell; J E Axon; A Blishen; A P Begg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  86     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  266-71     Citation Subset:  IM    
Affiliation:
Scone Veterinary Hospital, 106 Liverpool Street, Scone, NSW 2337. catherinerussell@bigpond.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*,  isolation & purification
Colony Count, Microbial / veterinary
Critical Illness
Decision Making
Dose-Response Relationship, Drug
Drug Resistance, Bacterial*
Female
Gram-Negative Bacteria / drug effects,  isolation & purification
Gram-Positive Bacteria / drug effects,  isolation & purification
Horse Diseases / drug therapy,  microbiology*
Horses
Male
Microbial Sensitivity Tests / veterinary
Retrospective Studies
Sepsis / drug therapy,  microbiology,  veterinary*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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