Document Detail

Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis.
MedLine Citation:
PMID:  10325788     Owner:  NLM     Status:  MEDLINE    
AIM: To determine whether pancreatitis associated protein (PAP) is a marker for cystic fibrosis which could be used in neonatal screening for the disease. METHODS: PAP was assayed on screening cards from 202,807 neonates. Babies with PAP > or = 15 ng/ml, or > or = 11.5 ng/ml and immunoreactive trypsinogen (IRT) > or = 700 ng/ml were recalled for clinical examination, sweat testing, and cystic fibrosis transmembrane regulator (CFTR) gene analysis. RESULTS: Median PAP value was 2.8 ng/ml. Forty four cases of cystic fibrosis were recorded. Recalled neonates (n = 398) included only 11 carriers. A receiver operating characteristic curve analysis showed that PAP above 8.0 ng/ml would select 0.76% of babies, including all those with cystic fibrosis, except for one with meconium ileus and two with mild CFTR mutations. Screening 27,146 babies with both PAP and IRT showed that only 0.12% had PAP > 8.0 ng/ml and IRT > 700 ng/ml, including all cases of cystic fibrosis. CONCLUSION: PAP is increased in most neonates with cystic fibrosis and could be used for CF screening. Its combination with IRT looks promising.
J Sarles; S Barthellemy; C F?rec; J Iovanna; M Roussey; J P Farriaux; A Toutain; J Berthelot; N Maurin; J P Codet; P Berth?z?ne; J C Dagorn
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  80     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2010-02-08    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F118-22     Citation Subset:  AIM; IM    
INSERM U.315 Marseille, France.
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MeSH Terms
Acute-Phase Proteins / analysis*
Antigens, Neoplasm*
Biological Markers / blood
Cystic Fibrosis / blood,  diagnosis*,  genetics
Cystic Fibrosis Transmembrane Conductance Regulator / genetics
Infant, Newborn
Lectins, C-Type*
Neonatal Screening / methods*
Predictive Value of Tests
Prospective Studies
Trypsinogen / blood
Tumor Markers, Biological*
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Antigens, Neoplasm; 0/Biological Markers; 0/CFTR protein, human; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 9002-08-8/Trypsinogen

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