| Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis. | |
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MedLine Citation:
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PMID: 10325788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine whether pancreatitis associated protein (PAP) is a marker for cystic fibrosis which could be used in neonatal screening for the disease. METHODS: PAP was assayed on screening cards from 202,807 neonates. Babies with PAP > or = 15 ng/ml, or > or = 11.5 ng/ml and immunoreactive trypsinogen (IRT) > or = 700 ng/ml were recalled for clinical examination, sweat testing, and cystic fibrosis transmembrane regulator (CFTR) gene analysis. RESULTS: Median PAP value was 2.8 ng/ml. Forty four cases of cystic fibrosis were recorded. Recalled neonates (n = 398) included only 11 carriers. A receiver operating characteristic curve analysis showed that PAP above 8.0 ng/ml would select 0.76% of babies, including all those with cystic fibrosis, except for one with meconium ileus and two with mild CFTR mutations. Screening 27,146 babies with both PAP and IRT showed that only 0.12% had PAP > 8.0 ng/ml and IRT > 700 ng/ml, including all cases of cystic fibrosis. CONCLUSION: PAP is increased in most neonates with cystic fibrosis and could be used for CF screening. Its combination with IRT looks promising. |
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Authors:
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J Sarles; S Barthellemy; C F?rec; J Iovanna; M Roussey; J P Farriaux; A Toutain; J Berthelot; N Maurin; J P Codet; P Berth?z?ne; J C Dagorn |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 80 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2010-02-08 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F118-22 Citation Subset: AIM; IM |
Affiliation:
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INSERM U.315 Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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analysis* Antigens, Neoplasm* Biological Markers / blood Cystic Fibrosis / blood, diagnosis*, genetics Cystic Fibrosis Transmembrane Conductance Regulator / genetics Humans Infant, Newborn Lectins, C-Type* Neonatal Screening / methods* Predictive Value of Tests Prospective Studies Trypsinogen / blood Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Antigens, Neoplasm; 0/Biological Markers; 0/CFTR protein, human; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 9002-08-8/Trypsinogen |
| Comments/Corrections | |
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