| Blood concentrations of midazolam in status epilepticus using an appropriate condition of HPLC. | |
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MedLine Citation:
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PMID: 20003143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of the present study was to determine an index to evaluate the efficacy and safety of midazolam (MDZ) to treat status epilepticus (SE). An original system was therefore developed to measure blood concentrations of MDZ and 1-hydroxymidazolam (1-OHMDZ) as the main metabolite on high-performance liquid chromatography. METHODS: This system was established through inspection of chromatograms, calibration curves and coefficient of correlations of MDZ. The clinical course of 11 SE patients, ranging from 4 months to 10 years of age, are described. These patients were treated with MDZ and measured at each blood concentration of MDZ. Moreover, patients were evaluated on cranial computed tomography and magnetic resonance imaging and video electroencephalogram (EEG), and it was determined that their seizures disappeared in accordance with the disappearance of convulsions and interictal EEG findings. RESULTS: Reproducibility was good with this system. The standard curves of MDZ and 1-OHMDZ were almost straight, and the correlation coefficients of MDZ and 1-OHMDZ were r = 0.9999 and r = 0.9998, respectively. The convulsions in nine of 11 SE patients disappeared without side-effects and the blood concentrations of MDZ in all the patients were measured. The mean peak blood concentrations of MDZ and 1-OHMDZ were higher than those reported in other studies. CONCLUSIONS: The clinical utility of this system has been demonstrated. An index to evaluate the efficacy and safety of MDZ is necessary, and MDZ blood concentrations measured on the present original precise measuring system could help in establishing a plan to successfully treat SE. |
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Authors:
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Toshiyuki Iwasaki; Yutaka Nonoda; Masahiro Ishii; Makiko Osawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 52 ISSN: 1442-200X ISO Abbreviation: Pediatr Int Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 513-9 Citation Subset: IM |
Copyright Information:
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© 2010 Japan Pediatric Society. |
Affiliation:
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Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan. tiwasaki@kitasatou.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Chromatography, High Pressure Liquid* Female Humans Infant Male Midazolam / analogs & derivatives, pharmacokinetics*, therapeutic use Status Epilepticus / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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59467-70-8/Midazolam; 59468-90-5/1-hydroxymethylmidazolam |
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