| Blood coagulation and fibrinolysis after experimental subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 20559667 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Aneurysmal rebleeding poses a serious risk in patients with subarachnoid hemorrhage (SAH). Studies have shown that antifibrinolytic therapy with tranexamic acid has a dramatic effect on the rate of rebleeding. Therefore, changes in the fibrinolytic system could be hypothesized. METHODS: We have used an experimental SAH rat model to demonstrate serial changes in the haemostatic system as evaluated by Thromboelastography (TEG). RESULTS: In the SAH group, a shorter reaction time (R-time) and higher maximum amplitude (MA) were observed. In the saline group, only a shorter R-time was observed. CONCLUSIONS: The study has shown that a hypercoagulable state is present immediately after experimental SAH is induced as determined by TEG. The reduction in R-time and rise in MA observed in the SAH group indicate that blood in the subarachnoid space is necessary to accomplish a full systemic coagulation response. This abnormality in coagulation profile seems to be a response to the acute traumatic event caused by induction of SAH. |
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Authors:
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Carl C Larsen; Jacob Hansen-Schwartz; Jørn D Nielsen; Jens Astrup |
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Publication Detail:
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Type: Journal Article Date: 2010-06-18 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 152 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 1577-81; discussion 1581 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Glostrup University Hospital, Glostrup, Denmark. larsen-cc@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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