Document Detail

Blood coagulation and fibrinolysis activation during sudden arterial occlusion of lower extremities--an association with ischemia and patient outcome.
MedLine Citation:
PMID:  8772217     Owner:  NLM     Status:  MEDLINE    
We compared hemostatic and fibrinolytic plasma markers in 41 patients having acute or subacute occlusion of lower limb arteries with 20 patients suffering stable peripheral arterial occlusive disease (PAOD). During occlusion, the amount of thrombin-antithrombin III (TAT) complex was five-fold higher compared with stable PAOD, being 16 micrograms/l [95% confidence interval (CI) 11-21 micrograms/l] vs 3 micrograms/l (95% CI 2-4 micrograms/l), p < 0.003. Similarly, D-dimer was over four-fold (p = 0.0001), while tissue plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) antigens were about two-fold (p = 0.02 and p < 0.003, respectively) higher than in PAOD. Coagulation and fibrinolysis markers were increased most in patients with recent symptom onset, which mainly represented embolus rather than thrombosis. The marker levels assessing coagulation and fibrinolysis were related with myoglobin and CK, indicators of skeletal muscle damage. Finally, increased TAT, PAI-1 antigen, and myoglobin concentrations associated with poor outcome.
S Peltonen; R Lassila; P Rossi; J P Salenius; M Lepäntalo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  74     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1442-6     Citation Subset:  IM    
Wihuri Research Institute, Helsinki, Finland.
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MeSH Terms
Arterial Occlusive Diseases / blood*,  complications
Blood Coagulation / physiology*
Case-Control Studies
Fibrinolysis / physiology*
Ischemia / blood*,  complications
Leg / blood supply*
Middle Aged

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