Document Detail


Blood coagulation and fibrinolysis activation during sudden arterial occlusion of lower extremities--an association with ischemia and patient outcome.
MedLine Citation:
PMID:  8772217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared hemostatic and fibrinolytic plasma markers in 41 patients having acute or subacute occlusion of lower limb arteries with 20 patients suffering stable peripheral arterial occlusive disease (PAOD). During occlusion, the amount of thrombin-antithrombin III (TAT) complex was five-fold higher compared with stable PAOD, being 16 micrograms/l [95% confidence interval (CI) 11-21 micrograms/l] vs 3 micrograms/l (95% CI 2-4 micrograms/l), p < 0.003. Similarly, D-dimer was over four-fold (p = 0.0001), while tissue plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) antigens were about two-fold (p = 0.02 and p < 0.003, respectively) higher than in PAOD. Coagulation and fibrinolysis markers were increased most in patients with recent symptom onset, which mainly represented embolus rather than thrombosis. The marker levels assessing coagulation and fibrinolysis were related with myoglobin and CK, indicators of skeletal muscle damage. Finally, increased TAT, PAI-1 antigen, and myoglobin concentrations associated with poor outcome.
Authors:
S Peltonen; R Lassila; P Rossi; J P Salenius; M Lepäntalo
Related Documents :
21823027 - Deep vein thrombosis: related to anemophilous pollen?
21612877 - A novel promising therapy for vein graft restenosis: overexpressed nogo-b induces vascu...
11960247 - Bilateral transpopliteal approach for treatment of complex sfa and iliac occlusions.
18340097 - Middle cerebral artery occlusion in the rabbit using selective angiography: application...
18272127 - Acute paraplegia and pulmonary edema after benzathine penicillin injection.
1947907 - Repeat coronary artery bypass grafting.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  74     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1442-6     Citation Subset:  IM    
Affiliation:
Wihuri Research Institute, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Arterial Occlusive Diseases / blood*,  complications
Blood Coagulation / physiology*
Case-Control Studies
Female
Fibrinolysis / physiology*
Humans
Ischemia / blood*,  complications
Leg / blood supply*
Male
Middle Aged
Prognosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Activation of the intrinsic pathway of coagulation in children with meningococcal septic shock.
Next Document:  Gelatin use impairs platelet adhesion during cardiac surgery.