| Blood coagulation disorders in septic patients. | |
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MedLine Citation:
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PMID: 20364416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Host defense and blood coagulation are tightly connected and interacting systems, necessary for the integrity of an organism. Complex mechanisms regulate the intensity of a host response to invading pathogens or other potentially dangerous situations. Under regular conditions, this response is limited in time and located to the site of injury. Sometimes, however, systemic host response is overwhelming and disproportional and causes damage, not cure. Dependent on the genetical predisposition of the host, its current immunocompetence, or the type of injury, the reaction leads to the clinical picture of the different degrees of sepsis. Septic organ dysfunction is caused by intravascular fibrin deposition as a result of coagulation activation, anticoagulant breakdown, and shut down of fibrinolysis. This article describes the major pathophysiologic reactions in these situations and presents www.SepDIC.eu, an online tool on sepsis and associated coagulopathy. |
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Authors:
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Paul Knoebl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Wiener medizinische Wochenschrift (1946) Volume: 160 ISSN: 1563-258X ISO Abbreviation: Wien Med Wochenschr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708475 Medline TA: Wien Med Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 129-38 Citation Subset: IM |
Affiliation:
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Division of Hematology and Hemostasis, Department of Medicine I, Medical University of Vienna, Vienna, Austria. paul.knoebl@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antithrombins
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physiology Apoptosis / physiology Blood Coagulation Disorders / physiopathology*, therapy Disseminated Intravascular Coagulation / physiopathology Endothelium, Vascular / physiopathology Fibrinolysis / physiology Humans Intensive Care Multiple Organ Failure / physiopathology Platelet Activation / physiology Sepsis / physiopathology*, therapy Systemic Inflammatory Response Syndrome / physiopathology Thrombin / physiology Thrombosis / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins; EC 3.4.21.5/Thrombin |
| Comments/Corrections | |
Comment In:
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Wien Med Wochenschr. 2010 Mar;160(5-6):105-6
[PMID:
20364411
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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