Document Detail


Blood clots in the cumulus-oocyte complex predict poor oocyte quality and post-fertilization development.
MedLine Citation:
PMID:  18549689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assessment of oocyte maturity and quality (morphological appearance) at the time of retrieval is difficult as the egg is obscured by a large cumulus mass that hinders adequate scoring. Since no data are available on the possible relationship between the cumulus-oocyte complex (COC) and oocyte morphology, this prospective intracytoplasmic sperm injection study was set up in 87 consecutive patients. COC were grouped according to expansion of both corona radiata and cumulus matrix. Special emphasis was placed on recording morphological anomalies of COC (inclusion of blood clots and amorphous clumps). For all mature ovae, quality was assessed and preimplantation development followed up to blastocyst stage if fertilized. The risk of not harvesting an oocyte was higher in COC with blood clots compared with normal cumulus matrices (P = 0.004). COC expansion did not allow for prediction of either nuclear status or quality of the egg. The presence of blood clots within the cumulus matrix was associated with reduced oocyte quality (dense central granulation), fertilization rate and blastocyst formation, compared with unaffected COC (P < 0.05). It may be postulated that COC showing blood inclusions derive from poor quality follicles, which has a detrimental effect on oocyte quality and further cleavage to blastocyst stage. Consequently, mechanical removal of blood clots cannot rescue the corresponding embryo.
Authors:
T Ebner; M Moser; O Shebl; M Sommergruber; C Yaman; G Tews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  16     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  801-7     Citation Subset:  IM    
Affiliation:
Landes-, Frauen- und Kinderklinik, IVF-Unit, Linz, Upper Austria, Austria. thomas.ebner@gespag.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Cumulus Cells / pathology*
Embryonic Development / physiology
Female
Humans
Oocytes / cytology*,  physiology
Prospective Studies
Sperm Injections, Intracytoplasmic
Thrombosis / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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