Document Detail

Blood-cerebrospinal fluid barrier alteration following intraventricularly administered cholera toxin.
MedLine Citation:
PMID:  2445419     Owner:  NLM     Status:  MEDLINE    
Cholera toxin (CT) has been reported to double cerebrospinal fluid (CSF) formation following its introduction into the ventricular system of cats and dogs. In our laboratory we noted that CT used in a similar fashion in rabbits and cats resulted in only a slight increase in CSF formation and was associated with a steadily rising protein content in the cisterna magna effluent. To further investigate this finding, rabbits and cats underwent ventriculo-cisternal perfusions, one group with CT introduced into the ventricles and the other without. In the rabbit only, radioiodinated serum albumin (125I-RISA) was given i.v. Other groups of rabbits had 125I-RISA or 125I-CT injected into the ventricles. The group of rabbits receiving intraventricular CT experienced a 4-10-fold elevation in the amount of both protein and 125I-RISA in the cisterna magna effluent compared with the control group. Electrophoretic pattern of the protein present in the effluent was similar to that of rabbit plasma. Autoradiography of the brains of those animals given intraventricular 125I-CT were found to have a very high uptake of 125I-CT in the choroid plexus and along all exposed ventricular surfaces, a finding not evident when 125I-RISA alone was given intraventricularly. It is concluded that CT altered the blood-CSF barriers allowing the reference marker to penetrate these barriers and plasma to leak into the CSF. These findings appear to account for most if not all of what was thought to be an increase in CSF formation in response to intraventricular CT.
S Hyman; J G McComb; L Megerdichian; M H Weiss
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain research     Volume:  419     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1988-01-11     Completed Date:  1988-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  104-11     Citation Subset:  IM    
Department of Neurologic Surgery, University of Southern California School of Medicine, Los Angeles 90027.
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MeSH Terms
Blood-Brain Barrier / drug effects*
Brain / drug effects,  metabolism
Cerebrospinal Fluid / drug effects,  metabolism*
Cerebrospinal Fluid Proteins / metabolism
Cholera Toxin / administration & dosage*
Injections, Intraventricular
Serum Albumin / administration & dosage,  metabolism
Species Specificity
Time Factors
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins; 0/Serum Albumin; 9004-54-0/Dextrans; 9012-63-9/Cholera Toxin; 9049-32-5/blue dextran

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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