Document Detail

Blood calcium levels in the presence of arteriographic contrast material.
MedLine Citation:
PMID:  1132114     Owner:  NLM     Status:  MEDLINE    
One of the complications of coronary angiography is a sudden and persistant fall in blood pressure. This may be due to the presence of calcium chelating agents in the vehicle of the radio-opaque compounds. Depressed ambient calcium levels are associated with decreased myocardial contractility and when low enough cause electromechanical dissociation. Simultaneous measurements of radial artery and coronary sinus ionized calcium levels in nine patients during intracoronary injection of the contrast agent revealed a lowering of the level of ionized calcium in the coronary sinus to a point that can be expected to be associated with a decrease in myocardial contractility. This ionized calcium depression was more marked and prolonged in patients with arteriosclerosis, some reaching levels which, if persistent, could result in electromechanical dissociation.
J B Caulfield; L Zir; J W Harthorne
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  52     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-08-29     Completed Date:  1975-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  AIM; IM    
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MeSH Terms
Arteriosclerosis / blood
Blood Pressure / drug effects
Calcium / blood*
Chelating Agents / adverse effects,  pharmacology
Contrast Media / administration & dosage,  adverse effects,  pharmacology*
Coronary Angiography*
Coronary Disease / blood,  radiography*
Depression, Chemical
Hypotension / chemically induced
Injections, Intra-Arterial
Myocardial Contraction / drug effects
Reg. No./Substance:
0/Chelating Agents; 0/Contrast Media; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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