Document Detail


Blood-brain barrier permeability in senescent rats.
MedLine Citation:
PMID:  438469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrovascular permeability to 14C-sucrose was measured in 3-mo-old and 28-mo-old conscious, restrained Fischer 344 male rats. Tracer was injected intravenously in these animals and arterial plasma concentrations were followed for 50 to 240 min, when animals were killed and regional brain radioactivity was measured. Equations derived by a two-compartment diffusion model were fit to concentration data to estimate PA (product of cerebral capillary permeability and surface area) and Ve (cerebral distribution space of 14C-sucrose). PA in 3-mo-old rats averaged 7.53 x 10(-6) sec-1 in 14 cerebral regions, and was not significantly elevated in 28-mo-old rats except possibly at white matter. Ve fell from an average of 0.126 in control rats to 0.070 in 28-mo-old rats. This 45% reduction may reflect a reduced extracellular space in the older animals. The findings do not support the hypothesis that aging of the central nervous system is related to breakdown of the blood-brain barrier.
Authors:
S I Rapoport; K Ohno; K D Pettigrew
Related Documents :
19010519 - Developmental levels of phospholipase d isozymes in the brain of developing rats.
2272969 - Regional h2o2 concentration in rat brain after hyperoxic convulsions.
19026729 - Lead-induced alteration of apoptotic proteins in different regions of adult rat brain.
11807399 - Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebr...
20599439 - Pharmacokinetics of acute and sub-chronic aripiprazole in p-glycoprotein deficient mice.
21752959 - Rat embryo exposure to all-trans retinoic acid results in postnatal oxidative damage of...
7861669 - Acetylcholine measurement of cerebrospinal fluid by in vivo microdialysis in freely mov...
21719739 - Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in ...
24106399 - Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gerontology     Volume:  34     ISSN:  0022-1422     ISO Abbreviation:  J Gerontol     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374762     Medline TA:  J Gerontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Blood Pressure
Blood-Brain Barrier*
Brain / blood supply,  metabolism
Capillary Permeability
Heart Rate
Male
Rats
Sucrose / blood,  metabolism
Chemical
Reg. No./Substance:
57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of ferrous sulfate on parathion degradation in flooded soil.
Next Document:  Trypsinization frequency and loss of proliferative capacity in WI-38 cells.