Document Detail

Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals.
MedLine Citation:
PMID:  104549     Owner:  NLM     Status:  MEDLINE    
The blood-brain barrier to intravascular Evans blue-albumin was opened in monkeys and rabbits by infusing isotonic saline for 15 s into the common carotid artery, when the external carotid was clamped temporarily and the lingual was catheterized for measuring pressure. Barrier opening correlated better with infusion pressure than with infusion rate, and occurred at carotid artery pressures above 170 mmHg. Systemic hypertension induced by Aramine increased barrier vulnerability by causing a higher net carotid artery pressure to be attained at a given infusion rate.
S I Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica: diagnosis     Volume:  19     ISSN:  0567-8056     ISO Abbreviation:  Acta Radiol Diagn (Stockh)     Publication Date:  1978  
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370367     Medline TA:  Acta Radiol Diagn (Stockh)     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  921-32     Citation Subset:  IM    
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MeSH Terms
Blood-Brain Barrier / drug effects*
Body Water / analysis
Brain Chemistry
Brain Edema / chemically induced
Carotid Artery, Internal
Coronary Circulation / drug effects
Electrolytes / analysis
Hypertension / physiopathology*
Injections, Intra-Arterial
Macaca mulatta
Metaraminol / pharmacology
Papaverine / pharmacology
Sodium Chloride / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Electrolytes; 54-49-9/Metaraminol; 58-74-2/Papaverine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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