| Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals. | |
MedLine Citation:
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PMID: 104549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood-brain barrier to intravascular Evans blue-albumin was opened in monkeys and rabbits by infusing isotonic saline for 15 s into the common carotid artery, when the external carotid was clamped temporarily and the lingual was catheterized for measuring pressure. Barrier opening correlated better with infusion pressure than with infusion rate, and occurred at carotid artery pressures above 170 mmHg. Systemic hypertension induced by Aramine increased barrier vulnerability by causing a higher net carotid artery pressure to be attained at a given infusion rate. |
Authors:
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S I Rapoport |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta radiologica: diagnosis Volume: 19 ISSN: 0567-8056 ISO Abbreviation: Acta Radiol Diagn (Stockh) Publication Date: 1978 |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370367 Medline TA: Acta Radiol Diagn (Stockh) Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 921-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / drug effects* Body Water / analysis Brain Chemistry Brain Edema / chemically induced Carotid Artery, Internal Constriction Coronary Circulation / drug effects Electrolytes / analysis Haplorhini Hypertension / physiopathology* Injections, Intra-Arterial Macaca mulatta Metaraminol / pharmacology Papaverine / pharmacology Rabbits Sodium Chloride / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 54-49-9/Metaraminol; 58-74-2/Papaverine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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