Document Detail


Blood-brain barrier integrity in a zolpidem-responder patient.
MedLine Citation:
PMID:  23034205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 27-year-old neurologically disabled but fully conscious male zolpidem-responder patient was investigated for blood brain barrier (BBB) dysfunction 5 years after a traumatic brain injury. A baseline single-photon emission computed tomography (SPECT) technetium-99m-labelled hexamethylpropylene amine oxime (99mTcHMPAO) brain scan was performed and the patient was administered 10 mg zolpidem daily. The patient was rescanned 2 weeks later when 99mTcHMPAO was injected 1 hour after zolpidem application. SPECT technetium-99m-labelled diethylene-triamine-pentacetic acid (99mTcDTPA) BBB scans were also performed before and after zolpidem treatment. There was decreased uptake of 99mTcHMPAO in the left frontoparietal brain region, left temporal region and left thalamus on baseline scanning; this improved within 1 hour after zolpidem treatment at the follow-up scan. The 99mTcDTPA scan remained within normal limits before and after zolpidem treatment. The patient's neurological disabilities, especially coordination, speech and gait, improved markedly. The Barthel Index remained normal, but the Tinetti falls efficacy scale improved from 21/100 to 15/100. The results implied that the underlying cause for the patient's long-term neurological disability and brain suppression was not due to a long-term dysfunctional BBB.
Authors:
N E Nyakale; R P Clauss; H W Nel; M M Sathekge
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-07-31
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  102     ISSN:  0038-2469     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2012-12-04     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  790-1     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood-Brain Barrier / physiopathology*,  radionuclide imaging
Brain Injuries / drug therapy*,  physiopathology*,  radionuclide imaging
GABA-A Receptor Agonists / therapeutic use*
Humans
Male
Pyridines / therapeutic use*
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/GABA-A Receptor Agonists; 0/Pyridines; 7K383OQI23/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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