| Blood-based biomarkers of Alzheimer's disease: challenging but feasible. | |
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MedLine Citation:
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PMID: 20387303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood-based biomarkers present a considerable challenge: technically, as blood is a complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless, increasing evidence suggests that there is a blood protein signature, and possibly a transcript signature, that might act to increase confidence in diagnosis, be used to predict progression in either disease or prodromal states, and that may also be used to monitor disease progression. Evidence for this optimism comes partly from candidate protein studies, including those suggesting that amyloid-beta measures might have value in prediction and those studies of inflammatory markers that consistently show change in Alzheimer's disease, and partly from true proteomics studies that are beginning to identify markers in blood that replicate across studies and populations. |
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Authors:
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Madhav Thambisetty; Simon Lovestone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biomarkers in medicine Volume: 4 ISSN: 1752-0363 ISO Abbreviation: Biomark Med Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-05-03 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 65-79 Citation Subset: IM |
Affiliation:
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Laboratory of Personality & Cognition, Intramural Research Program, National Institue on Aging, NIH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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blood*,
diagnosis,
genetics Amyloid beta-Peptides / blood Apolipoproteins E / genetics Biological Markers / blood* C-Reactive Protein / metabolism Genetic Markers Homocysteine / blood Humans Longitudinal Studies Proteomics RNA / blood, genetics |
| Grant Support | |
ID/Acronym/Agency:
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Z99 AG999999/AG/NIA NIH HHS; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Apolipoproteins E; 0/Biological Markers; 0/Genetic Markers; 454-28-4/Homocysteine; 63231-63-0/RNA; 9007-41-4/C-Reactive Protein |
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