Document Detail

Blood as a reactive species generator and redox status regulator during exercise.
MedLine Citation:
PMID:  19712664     Owner:  NLM     Status:  MEDLINE    
The exact origin of reactive species and oxidative damage detected in blood is largely unknown. Blood interacts with all organs and tissues and, consequently, with many possible sources of reactive species. In addition, a multitude of oxidizable substrates are already in blood. A muscle-centric approach is frequently adopted to explain reactive species generation, which obscures the possibility that sources of reactive species and oxidative damage other than skeletal muscle may be also at work during exercise. Plasma and blood cells can autonomously produce significant amounts of reactive species at rest and during exercise. The major reactive species generators located in blood during exercise may be erythrocytes (mainly due to their quantity) and leukocytes (mainly due to their drastic activation during exercise). Therefore, it is plausible to assume that oxidative stress/damage measured frequently in blood after exercise or any other experimental intervention derives, at least in part, from the blood.
Michalis G Nikolaidis; Athanasios Z Jamurtas
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-25
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  490     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2009-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Institute of Human Performance and Rehabilitation, Centre for Research and Technology-Thessaly, Trikala, Greece.
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MeSH Terms
Antioxidants / metabolism
Catalase / blood
Erythrocytes / metabolism
Exercise / physiology*
Glutathione Peroxidase / blood
Leukocytes / metabolism
Models, Biological
Oxidative Stress
Plasma / metabolism
Reactive Oxygen Species / blood*
Superoxide Dismutase / blood
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; EC; EC Peroxidase; EC Dismutase

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