| Blood as a reactive species generator and redox status regulator during exercise. | |
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MedLine Citation:
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PMID: 19712664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exact origin of reactive species and oxidative damage detected in blood is largely unknown. Blood interacts with all organs and tissues and, consequently, with many possible sources of reactive species. In addition, a multitude of oxidizable substrates are already in blood. A muscle-centric approach is frequently adopted to explain reactive species generation, which obscures the possibility that sources of reactive species and oxidative damage other than skeletal muscle may be also at work during exercise. Plasma and blood cells can autonomously produce significant amounts of reactive species at rest and during exercise. The major reactive species generators located in blood during exercise may be erythrocytes (mainly due to their quantity) and leukocytes (mainly due to their drastic activation during exercise). Therefore, it is plausible to assume that oxidative stress/damage measured frequently in blood after exercise or any other experimental intervention derives, at least in part, from the blood. |
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Authors:
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Michalis G Nikolaidis; Athanasios Z Jamurtas |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-08-25 |
Journal Detail:
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Title: Archives of biochemistry and biophysics Volume: 490 ISSN: 1096-0384 ISO Abbreviation: Arch. Biochem. Biophys. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2009-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372430 Medline TA: Arch Biochem Biophys Country: United States |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Affiliation:
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Institute of Human Performance and Rehabilitation, Centre for Research and Technology-Thessaly, Trikala, Greece. mnikol@pe.uth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism Catalase / blood Erythrocytes / metabolism Exercise / physiology* Glutathione Peroxidase / blood Homeostasis Humans Leukocytes / metabolism Models, Biological Oxidation-Reduction Oxidative Stress Plasma / metabolism Reactive Oxygen Species / blood* Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Reactive Oxygen Species; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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