| Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients. | |
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MedLine Citation:
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PMID: 7797389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P < 0.001) was found between the Kd of active HLA-B27 AAU (61.4 +/- 16.8 x 10(-4) min-1) and the Kd of inactive HLA-B27 AAU (4.8 +/- 1.6 x 10(-4) min-1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3 +/- 1.0 x 10(-4) min-1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. |
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Authors:
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J M Benitez del Castillo; N Toledano; A Bañares; C Hernandez; M Arjona; D Díaz Valle; J Garcia Sanchez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International ophthalmology Volume: 18 ISSN: 0165-5701 ISO Abbreviation: Int Ophthalmol Publication Date: 1994-1995 |
Date Detail:
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Created Date: 1995-07-31 Completed Date: 1995-07-31 Revised Date: 2006-07-19 |
Medline Journal Info:
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Nlm Unique ID: 7904294 Medline TA: Int Ophthalmol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Hospital Universitario San Carlos, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aqueous Humor / metabolism* Blood / metabolism* Capillary Permeability* Ciliary Body / blood supply Female Fluorescein Fluoresceins / metabolism Fluorophotometry HLA-B27 Antigen / metabolism* Humans Iris / blood supply Male Uveitis, Anterior / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; 0/HLA-B27 Antigen; 2321-07-5/Fluorescein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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