| Blood-aqueous barrier function in a patient with choroideremia. | |
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MedLine Citation:
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PMID: 20206842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose was to determine whether there was a breakdown of the blood-aqueous barrier in a patient with choroideremia. A 27-year-old man with typical choroideremia underwent standardized ophthalmo-logical evaluation, including quantitative measurement of aqueous flare intensity, by a laser flare-cell meter. The results showed areas of atrophy of the choriocapillaries and retinal pigment epithelium in the mid-periphery and posterior pole, although not in the macula. Fluorescein angiography showed areas of loss of the choriocapillaries and retinal pigment epithelium. The fovea was spared with a surrounding zone of hy-perfluorescence. Electroretinography showed a subnormal photopic amplitude and extinguished scotopic response. Electrooculography revealed that the light peak/dark trough ratio was reduced. Goldmann perimetry showed constricted peripheral fields. Laser photometry showed an increase in the aqueous flare intensity in both eyes, as compared with normal subjects. We conclude that the function of the blood-aqueous barrier might be affected in patients with choroideremia. |
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Authors:
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Muh-Shy Chen; Ching-Chung Chang; Tzyy-Chang Ho; Tzu-Hsun Tsai; I-More Fan; Ping-Kang Hou |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 109 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 167-71 Citation Subset: IM |
Copyright Information:
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(c) 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. chenmuhshy@ntu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aqueous Humor / metabolism Blood-Aqueous Barrier / physiopathology* Choroideremia / metabolism* Electrooculography Electroretinography Fluorescein Angiography Humans Male Photometry Retinal Diseases / metabolism* Retinal Pigment Epithelium* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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