| Blood ammonia and ventilation at maximal exercise. | |
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MedLine Citation:
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PMID: 10417855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study, intended to evaluate the role of ammonia (NH3) as a ventilatory stimulus, was conducted in three groups of subjects: 14 sedentary individuals, 12 triathletes, 5 patients with a glycolytic deficiency (Mc Ardle disease). All subjects performed maximal exercise tests on a cycle ergometer. Ventilation measured at maximal oxygen consumption (VE 100%) was correlated with lactatemia (lactate 100%) and ammonemia (NH3 100%) in the sedentary group, but only with ammonemia in triathletes, although NH3 100% and lactate 100% were correlated in both groups, which suggests that correlation between VE 100% and NH3 100% is not a false correlation. In patients with Mc Ardle disease, unable to produce lactate during exercise, VE 100% was correlated with NH3 100%. NH3 may act indirectly by increasing the production of lactate in cereberal tissue. Another hypothesis rests on the fact that the catabolism of ammonia leads to an increase in intracerebral glutamate which may act as a ventilatory stimulus. |
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Authors:
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D Vanuxem; S Delpierre; E Fauvelle; C Guillot; P Vanuxem |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of physiology and biochemistry Volume: 106 ISSN: 1381-3455 ISO Abbreviation: Arch. Physiol. Biochem. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-08-31 Completed Date: 1999-08-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9510153 Medline TA: Arch Physiol Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 290-6 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiologie Respiratoire, Faculté de Médecine Timone, Marseille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ammonia / blood* Exercise / physiology* Female Glycogen Storage Disease Type V / blood Glycolysis Humans Lactic Acid / blood Male Maximal Voluntary Ventilation / physiology* Middle Aged |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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